Ordering Recommendation

Use to monitor linear IgG and IgA basement membrane zone antibody-associated diseases and IgG and IgA cell surface antibody-associated diseases in which antibody levels by ELISAs may not be increased and/or to assess for changing patterns of epithelial antibody expression. May be used as general initial serum test for immunobullous diseases; however, for more sensitive and specific serum testing for pemphigoid and EBA or for IgG variant pemphigus, refer to Basement Membrane Zone Antibody Panel (3001410) or Pemphigus Antibody Panel, IgG (0090650).

Consider ordering concurrently with Bullous Pemphigoid (BP180 and BP230) Antibodies, IgG by ELISA (0092566) and Collagen Type VII Antibody, IgG by ELISA (2010905) for suspected pemphigoid, EBA, or other basement membrane zone antibody-associated diseases. Consider ordering with Desmoglein 1 and Desmoglein 3 (Pemphigus) Antibodies, IgG by ELISA (0090649) for suspected pemphigus. Alternatively, consider Immunobullous Disease Antibody Panel (3001409) for comprehensive assessment.

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.


Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely


Semi-Quantitative Indirect Immunofluorescence (IIF)




4-9 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory


For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History


CPT Codes

88346; 88350 x5


Component Test Code* Component Chart Name LOINC
0090298 Epithelial Skin Antibodies
3004038 EER Epithelial Skin Antibodies 66877-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • atypical epithelial antibody-associated disease
  • basement membrane zone antibody-associated disease
  • bullous disease of childhood
  • bullous lupus erythematosus
  • bullous pemphigoid
  • childhood immunobullous disease
  • chronic bullous disease of childhood
  • cicatricial pemphigoid
  • desmosomal protein antibodies
  • desmosome antibodies
  • endemic pemphigus
  • epidermolysis bullosa acquisita
  • epithelial antibody-associated disease
  • Epithelial Skin Antibody Panel
  • fogo selvagem
  • hemidesmosomal protein antibodies
  • hemidesmosome antibodies
  • ICS antibodies
  • IgA pemphigus
  • IgG/IgA basement membrane zone antibodies
  • indirect fluorescence assay
  • indirect fluorescent antibody (IFA)
  • indirect immunofluorescent assay
  • intercellular IgG/IgA dermatosis
  • intercellular substance antibodies
  • intraepidermal neutrophilic IgA dermatosis
  • linear IgA bullous dermatosis
  • linear IgA disease
  • linear IgG/IgA bullous dermatosis
  • mixed epithelial antibody-associated disease
  • mixed immunobullous disease of childhood
  • mucous membrane pemphigoid
  • ocular cicatricial pemphigoid
  • pemphigoid variants
  • pemphigus erythematosus
  • pemphigus foliaceus
  • pemphigus vegetans
  • pemphigus vulgaris
  • salt-split skin test
  • subcorneal pustular dermatosis
  • subepithelial immunobullous disease
Basement Membrane Zone and Cell Surface (Epithelial) Antibodies, IgG and IgA by IIF