Ordering Recommendation

Use as general initial test for immunobullous diseases or to monitor epidermolysis bullosa acquisita (EBA) and linear IgA disease antibody expression.

Components include Epithelial Basement Membrane Zone IgG Antibodies (0092056) and Epithelial Basement Membrane Zone IgA Antibodies (0092057) (diagnostic disease markers in pemphigoid, epidermolysis bullosa acquisita, linear IgA disease) and Epithelial Cell Surface Antibody IgG (0090266) and Pemphigus Antibody IgA (0092106) (diagnostic disease markers in IgG and IgA pemphigus subtypes); test does not include ELISAs for specific disease-related antigenic targets.

Consider ordering concurrently with Bullous Pemphigoid Antigens (180 kDa and 230 kDa), IgG (0092566) and Collagen Type VII Antibody IgG by ELISA (2010905) for suspected pemphigoid or EBA. Consider ordering with Desmoglein 1 and Desmoglein 3 Antibodies in Pemphigus, IgG (0090649) for suspected pemphigus. Consider ordering the Immunobullous Disease Panel, Epithelial (3001409), which includes IgG and IgA epithelial cell surface and basement membrane zone antibodies and IgG desmoglein 1 and 3, IgG BP180 and BP 230, and IgG collagen type VII antibodies.

For more sensitive and specific testing for pemphigoid and EBA or pemphigus, refer to Basement Membrane Zone Antibody Panel (3001410) or Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650).

Mnemonic
EPITHELIAL
Methodology

Semi-Quantitative Indirect Fluorescent Antibody (IFA)

Performed

Varies

Reported

4-9 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



Compliance Category

Not Applicable

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History
N/A
CPT Codes

88346; 88350 x5

Components
Component Test Code* Component Chart Name LOINC
0090298 Epithelial Skin Antibodies
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Epithelial Skin Antibody