Basement Membrane Zone and Cell Surface (Epithelial) Antibodies, IgG and IgA by IIF
Ordering Recommendation
Use to monitor linear IgG and IgA basement membrane zone antibody-associated diseases and IgG and IgA cell surface antibody-associated diseases in which antibody levels by ELISAs may not be increased and/or to assess for changing patterns of epithelial antibody expression. May be used as general initial serum test for immunobullous diseases; however, for more sensitive and specific serum testing for pemphigoid and EBA or for IgG variant pemphigus, refer to Basement Membrane Zone Antibody Panel (3001410) or Pemphigus Antibody Panel, IgG (0090650).
Consider ordering concurrently with Bullous Pemphigoid (BP180 and BP230) Antibodies, IgG by ELISA (0092566) and Collagen Type VII Antibody, IgG by ELISA (2010905) for suspected pemphigoid, EBA, or other basement membrane zone antibody-associated diseases. Consider ordering with Desmoglein 1 and Desmoglein 3 (Pemphigus) Antibodies, IgG by ELISA (0090649) for suspected pemphigus. Alternatively, consider Immunobullous Disease Antibody Panel (3001409) for comprehensive assessment.
For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Hemolyzed or lipemic specimens. Plasma.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Methodology
Semi-Quantitative Indirect Immunofluorescence (IIF)
Performed
Varies
Reported
4-9 days
Reference Interval
By report
Interpretive Data
Refer to report
Performed by non-ARUP Laboratory
Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
Hotline History
Hotline History
CPT Codes
88346; 88350 x5
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0090298 | Epithelial Skin Antibodies | |
3004038 | EER Epithelial Skin Antibodies | 66877-2 |
Aliases
- atypical epithelial antibody-associated disease
- basement membrane zone antibody-associated disease
- bullous disease of childhood
- bullous lupus erythematosus
- bullous pemphigoid
- childhood immunobullous disease
- chronic bullous disease of childhood
- cicatricial pemphigoid
- desmosomal protein antibodies
- desmosome antibodies
- endemic pemphigus
- epidermolysis bullosa acquisita
- epithelial antibody-associated disease
- Epithelial Skin Antibody Panel
- fogo selvagem
- hemidesmosomal protein antibodies
- hemidesmosome antibodies
- ICS antibodies
- IgA pemphigus
- IgG/IgA basement membrane zone antibodies
- indirect fluorescence assay
- indirect fluorescent antibody (IFA)
- indirect immunofluorescent assay
- intercellular IgG/IgA dermatosis
- intercellular substance antibodies
- intraepidermal neutrophilic IgA dermatosis
- linear IgA bullous dermatosis
- linear IgA disease
- linear IgG/IgA bullous dermatosis
- mixed epithelial antibody-associated disease
- mixed immunobullous disease of childhood
- mucous membrane pemphigoid
- ocular cicatricial pemphigoid
- pemphigoid variants
- pemphigus erythematosus
- pemphigus foliaceus
- pemphigus vegetans
- pemphigus vulgaris
- salt-split skin test
- subcorneal pustular dermatosis
- subepithelial immunobullous disease