Ordering Recommendation

• For disease monitoring in patients diagnosed with epidermolysis bullosa acquisita (EBA) or bullous lupus erythematosus and increased IgG type VII collagen antibody levels.
• To further evaluate IgG BMZ antibodies, consider ordering with Epithelial Basement Membrane Zone Antibody IgG (0092056) and Bullous Pemphigoid Antigens (180 kDa and 230 kDa), IgG (0092566).
• Consider other types of BMZ antibody-associated disease testing (ie, Epithelial Basement Membrane Zone Antibody IgA (0092057) and Herpes Gestationis Factor (Complement-Fixing Basement Membrane Zone Antibody IgG) (0092283)).
• To discriminate among the immunobullous skin diseases in patients suspected or known to have any type of immunobullous disease, order concurrently with testing for Epithelial Skin Antibody (0090299) or refer to Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies, IgG and IgA, BP180 and BP230 Antibodies, IgG (0092001) and Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650).
• For initial diagnosis and assessment of disease progression/changes and intermittent monitoring, preferred test is Immunobullous Disease Panel, Epithelial (3001409), or Basement Membrane Zone Antibody Panel (3001410); both panels include Collagen Type VII Antibody IgG by ELISA. 

Mnemonic
COLLAG 7
Methodology

Enzyme-Linked Immunosorbent Assay

Performed

Varies

Reported

14-17 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



No compliance statements are in use for this test.

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History
N/A
Components
Component Test Code* Component Chart Name LOINC
2010906 Collagen Type VII Antibody IgG by ELISA
2010907 EER Collagen Type VII Ab IgG, by ELISA
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Collagen Type VII Antibody IgG by ELISA