Collagen Type VII Antibody IgG by ELISA

Use to monitor disease in patients diagnosed with epidermolysis bullosa acquisita (EBA) or bullous lupus erythematosus and increased IgG type VII collagen antibody levels.

For initial diagnosis, preferred test is Immunobullous Disease Panel, Epithelial (3001409) or Basement Membrane Zone Antibody Panel (3001410); both panels include this test.

To further evaluate IgG basement membrane zone antibodies for assessment of disease progression/changes and intermittent monitoring, consider ordering with Epithelial Basement Membrane Zone Antibody IgG (0092056) and Bullous Pemphigoid Antigens (180 kDa and 230 kDa), IgG (0092566); consider other types of basement membrane zone antibody-associated disease testing [ie, Epithelial Basement Membrane Zone Antibody IgA (0092057) and Herpes Gestationis Factor (Complement-Fixing Basement Membrane Zone Antibody IgG) (0092283)].

To discriminate among the immunobullous skin diseases in patients suspected or known to have any type of immunobullous disease, order concurrently with Epithelial Skin Antibody (0090299) or refer to Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies, IgG and IgA, BP180 and BP230 Antibodies, IgG (0092001) and Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650).