Ordering Recommendation

Use to monitor disease in patients diagnosed with pemphigus and increased IgG desmoglein 1 and/or 3 antibodies; antibody levels correlate with disease activity. Consider ordering with Epithelial Cell Surface Antibody IgG (0090266).

Decreased diagnostic sensitivity and specificity when testing for pemphigus compared with Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650).

For initial diagnosis, the preferred test is Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650) or Immunobullous Disease Panel, Epithelial (3001409).

For assessment of disease progression/changes and intermittent monitoring, the preferred test is Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650).

For diagnosing rare types of pemphigus, refer to Pemphigus Antibody IgA (0092106) and Paraneoplastic Pemphigus Antibody Screen (0092107).

Mnemonic
IGG DESMOG
Methodology

Enzyme-Linked Immunosorbent Assay

Performed

Varies

Reported

4-9 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plain red or serum separator tube.

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



No compliance statements are in use for this test.

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History
N/A
CPT Codes

83516 x2

Components
Component Test Code* Component Chart Name LOINC
0090653 Desmoglein 1 and 3 Antibodies, IgG 19146-0
2010912 EER Desmoglein 1 and 3 Antibodies, IgG 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Desmoglein 1 and Desmoglein 3 Antibodies in Pemphigus, IgG