Desmoglein 1 and Desmoglein 3 (Pemphigus) Antibodies, IgG by ELISA

Use to monitor disease in individuals diagnosed with various pemphigus variants who have increased IgG desmoglein 1 and/or IgG desmoglein 3 antibodies. Antibody levels correlate with disease activity. 

For initial diagnosis, Pemphigus Antibody Panel, IgG (0090650) has greater diagnostic sensitivity and specificity and is preferred in the assessment of disease progression/changes and for intermittent monitoring of IgG pemphigus variants. For more comprehensive evaluation, consider Immunobullous Disease Antibody Panel (3001409). For diagnostic testing for rare types of pemphigus, refer to Pemphigus Antibodies, IgA by IIF (0092106) and Paraneoplastic Pemphigus (Paraneoplastic Autoimmune Multiorgan Syndrome) Screening Antibodies by IIF (0092107).

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.