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Desmoglein 1 and Desmoglein 3 (Pemphigus) Antibodies, IgG by ELISA
Ordering Recommendation
Use to monitor disease in individuals diagnosed with various pemphigus variants who have increased IgG desmoglein 1 and/or IgG desmoglein 3 antibodies. Antibody levels correlate with disease activity.
For initial diagnosis, Pemphigus Antibody Panel, IgG (0090650) has greater diagnostic sensitivity and specificity and is preferred in the assessment of disease progression/changes and for intermittent monitoring of IgG pemphigus variants. For more comprehensive evaluation, consider Immunobullous Disease Antibody Panel (3001409). For diagnostic testing for rare types of pemphigus, refer to Pemphigus Antibodies, IgA by IIF (0092106) and Paraneoplastic Pemphigus (Paraneoplastic Autoimmune Multiorgan Syndrome) Expanded Antibody Panel by IIF With ELISA (3016534).
For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)
Refrigerated/ambient
Hemolyzed or lipemic specimens. Plasma.
As a general rule, serum specimens should be shipped to the laboratory as soon as possible.
Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Methodology
Semi-QuantitativeEnzyme-Linked Immunosorbent Assay (ELISA)
Performed
Varies
Reported
3-9 days
Reference Interval
By report
Interpretive Data
Refer to report
Performed by non-ARUP Laboratory
Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.
Hotline History
CPT Codes
83516 x2
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0090653 | Desmoglein 1 and 3 Antibodies, IgG | 19146-0 |
| 2010912 | EER Desmoglein 1 and 3 Antibodies, IgG | 11526-1 |
Aliases
- pemphigus foliaceus
- IgG pemphigus variant
- IgG variant pemphigus
- intercellular substance (ICS) antibodies
- pemphigus
- prickle cell antibodies
- Senear-Usher
- Test previously known as: Desmoglein 1 and Desmoglein 3 Antibodies in Pemphigus, IgG
- endemic pemphigus
- fogo selvagem
- pemphigus erythematosus
- desmosomal protein antibodies
- desmosome antibodies
- ICS antibodies
- pemphigus vulgaris
- pemphigus vegetans
- intercellular IgG/IgA dermatosis
