0090649
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Desmoglein 1 and Desmoglein 3 (Pemphigus) Antibodies, IgG by ELISA

IGG DESMOG
Example Reports
Enhanced Report
Negative
Positive

Ordering Recommendation

Use to monitor disease in individuals diagnosed with various pemphigus variants who have increased IgG desmoglein 1 and/or IgG desmoglein 3 antibodies. Antibody levels correlate with disease activity. 

For initial diagnosis, Pemphigus Antibody Panel, IgG (0090650) has greater diagnostic sensitivity and specificity and is preferred in the assessment of disease progression/changes and for intermittent monitoring of IgG pemphigus variants. For more comprehensive evaluation, consider Immunobullous Disease Antibody Panel (3001409). For diagnostic testing for rare types of pemphigus, refer to Pemphigus Antibodies, IgA by IIF (0092106) and Paraneoplastic Pemphigus (Paraneoplastic Autoimmune Multiorgan Syndrome) Expanded Antibody Panel by IIF With ELISA (3016534).

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated/ambient

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.

Remarks

As a general rule, serum specimens should be shipped to the laboratory as soon as possible.
Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.

Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Varies

Reported

3-9 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.

Hotline History

N/A

CPT Codes

83516 x2

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Components

Component Test Code* Component Chart Name LOINC
0090653 Desmoglein 1 and 3 Antibodies, IgG 19146-0
2010912 EER Desmoglein 1 and 3 Antibodies, IgG 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • desmosomal protein antibodies
    desmosome antibodies
    endemic pemphigus
    fogo selvagem
    ICS antibodies
    IgG pemphigus variant
    IgG variant pemphigus
    intercellular IgG/IgA dermatosis
    intercellular substance (ICS) antibodies
    pemphigus
    pemphigus erythematosus
    pemphigus foliaceus
    pemphigus vegetans
    pemphigus vulgaris
    prickle cell antibodies
    Senear-Usher
    Test previously known as: Desmoglein 1 and Desmoglein 3 Antibodies in Pemphigus, IgG
Desmoglein 1 and Desmoglein 3 (Pemphigus) Antibodies, IgG by ELISA