Ordering Recommendation
Use to monitor disease in patients diagnosed with various pemphigus variants and increased IgG desmoglein 1 and/or IgG desmoglein 3 antibodies; antibody levels correlate with disease activity.
For initial diagnosis, Pemphigus Antibody Panel, IgG (0090650) has greater diagnostic sensitivity and specificity and is preferred in the assessment of disease progression/changes and for intermittent monitoring of IgG pemphigus variants. For more comprehensive evaluation, consider Immunobullous Disease Antibody Panel (3001409). For diagnosing rare types of pemphigus, refer to Pemphigus Antibodies, IgA by IIF (0092106) and Paraneoplastic Pemphigus (Paraneoplastic Autoimmune Multiorgan Syndrome) Antibody Screening Panel (0092107).
For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.
Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Varies
Reported
3-9 days
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Hemolyzed or lipemic specimens. Plasma.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Reference Interval
By report
Interpretive Data
Refer to report
Performed by non-ARUP Laboratory
Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
Hotline History
Hotline History
CPT Codes
83516 x2
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0090653 | Desmoglein 1 and 3 Antibodies, IgG | 19146-0 |
2010912 | EER Desmoglein 1 and 3 Antibodies, IgG | 11526-1 |
Aliases
- Desmoglein 1 and Desmoglein 3 Antibodies in Pemphigus, IgG
- desmosomal protein antibodies
- desmosome antibodies
- endemic pemphigus
- fogo selvagem
- ICS antibodies
- intercellular IgG/IgA dermatosis
- intercellular substance antibodies
- pemphigus
- pemphigus erythematosus
- pemphigus foliaceus
- pemphigus vegetans
- pemphigus vulgaris