Ordering Recommendation

Use to monitor disease in individuals diagnosed with various pemphigus variants who have increased IgG desmoglein 1 and/or IgG desmoglein 3 antibodies. Antibody levels correlate with disease activity. 

For initial diagnosis, Pemphigus Antibody Panel, IgG (0090650) has greater diagnostic sensitivity and specificity and is preferred in the assessment of disease progression/changes and for intermittent monitoring of IgG pemphigus variants. For more comprehensive evaluation, consider Immunobullous Disease Antibody Panel (3001409). For diagnostic testing for rare types of pemphigus, refer to Pemphigus Antibodies, IgA by IIF (0092106) and Paraneoplastic Pemphigus (Paraneoplastic Autoimmune Multiorgan Syndrome) Expanded Antibody Panel by IIF With ELISA (3016534).

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.


As a general rule, serum specimens should be shipped to the laboratory as soon as possible.

Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.


Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely


Semi-QuantitativeEnzyme-Linked Immunosorbent Assay (ELISA)




3-9 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory


For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.

Hotline History


CPT Codes

83516 x2


Component Test Code* Component Chart Name LOINC
0090653 Desmoglein 1 and 3 Antibodies, IgG 19146-0
2010912 EER Desmoglein 1 and 3 Antibodies, IgG 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • desmosomal protein antibodies
  • desmosome antibodies
  • endemic pemphigus
  • fogo selvagem
  • ICS antibodies
  • IgG pemphigus variant
  • IgG variant pemphigus
  • intercellular IgG/IgA dermatosis
  • intercellular substance (ICS) antibodies
  • pemphigus
  • pemphigus erythematosus
  • pemphigus foliaceus
  • pemphigus vegetans
  • pemphigus vulgaris
  • prickle cell antibodies
  • Senear-Usher
  • Test previously known as: Desmoglein 1 and Desmoglein 3 Antibodies in Pemphigus, IgG
Desmoglein 1 and Desmoglein 3 (Pemphigus) Antibodies, IgG by ELISA