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Desmoglein 1 and Desmoglein 3 Antibodies in Pemphigus, IgG
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Ordering Recommendation
Use to monitor disease in patients diagnosed with pemphigus and increased IgG desmoglein 1 and/or 3 antibodies; antibody levels correlate with disease activity. Consider ordering with Epithelial Cell Surface Antibody IgG (0090266).
Decreased diagnostic sensitivity and specificity when testing for pemphigus compared with Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650).
For initial diagnosis, the preferred test is Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650) or Immunobullous Disease Panel, Epithelial (3001409).
For assessment of disease progression/changes and intermittent monitoring, the preferred test is Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650).
For diagnosing rare types of pemphigus, refer to Pemphigus Antibody IgA (0092106) and Paraneoplastic Pemphigus Antibody Screen (0092107).
Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Varies
Reported
4-9 days
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube.
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Hemolyzed or lipemic specimens.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Reference Interval
By report
Interpretive Data
Not Applicable
Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
Hotline History
CPT Codes
83516 x2
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0090653 | Desmoglein 1 and 3 Antibodies, IgG | 19146-0 |
| 2010912 | EER Desmoglein 1 and 3 Antibodies, IgG | 11526-1 |
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