Ordering Recommendation

Use to monitor disease in patients diagnosed with pemphigoid and increased IgG BP180 and/or BP230 antibody levels. For initial pemphigoid diagnosis that discriminates among immunobullous diseases and for assessment of disease progression/changes and intermittent monitoring, the Basement Membrane Zone Antibody Panel (3001410) or Immunobullous Disease Antibody Panel (3001409) is preferred. In a relevant clinical setting, consider Pemphigoid Gestationis, Complement-Fixing Basement Membrane Antibodies (Herpes Gestationis Factor) (0092283).

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated/Ambient

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.

Remarks

As a general rule, serum specimens should be shipped to the laboratory as soon as possible.
Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.

Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Varies

Reported

3-9 days

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Performed by non-ARUP Laboratory

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.

Hotline History

N/A

CPT Codes

83516 x2

Components

Component Test Code* Component Chart Name LOINC
0092568 Bullous Pemphigoid Antigens, IgG 57911-0
2010915 EER Bullous Pemphigoid Antigens, IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • BP Antigen 1
  • BP Antigen 2
  • BP180 and BP230
  • bullous pemphigoid
  • Bullous Pemphigoid (180 & 230) Antigens
  • bullous pemphigoid antigen 1 or BPAg1
  • bullous pemphigoid antigen 2 or BPAg2
  • collagen type 17
  • epidermal basement membrane zone (roof) antibodies on split skin substrate (salt split skin)
  • hemidesmosomal protein antibodies
  • hemidesmosome antibodies
  • herpes gestationis
  • NC16A
  • pemphigoid gestationis
  • pemphigoid variants, IgG BP 180 and BP 230
  • salt-split skin roof antibodies
  • type XVII collagen, collagen type XVII
Bullous Pemphigoid (BP180 and BP230) Antibodies, IgG by ELISA