Ordering Recommendation

Use to monitor disease in patients diagnosed with pemphigoid and increased IgG BP180 and/or BP230 antibody levels; IgG BP180 antibody levels correlate with disease activity in some patients.

For initial diagnosis and assessment of disease progression/changes and intermittent monitoring, preferred test is Basement Membrane Zone Antibody Panel (3001410) or Immunobullous Disease Panel, Epithelial (3001409).

Epithelial Basement Membrane Zone Antibody IgG (0092056) can be used to determine the involvement of IgG basement membrane zone antibodies and pattern of reactivity on split skin substrate. Consider other basement membrane zone antibody-associated disease testing (ie, Epithelial Basement Membrane Zone Antibody IgA [0092057], Collagen Type VII Antibody IgG by ELISA [2010905], or Herpes Gestationis Factor (Complement-Fixing Basement Membrane Zone Antibody IgG) [0092283]).

For initial pemphigoid diagnosis, Basement Membrane Zone Antibody Panel (3001410) or  Immunobullous Disease Panel, Epithelial (3001409) is preferred.

Mnemonic
BP180 230G
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Varies

Reported

3-11 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



No compliance statements are in use for this test.

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History
N/A
CPT Codes

83516 x2

Components
Component Test Code* Component Chart Name LOINC
0092568 Bullous Pemphigoid Antigens, IgG 57911-0
2010915 EER Bullous Pemphigoid Antigens, IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • BP 180 and BP 230
  • BP Antigen 1
  • BP Antigen 2
Bullous Pemphigoid Antigens (180 kDa and 230 kDa), IgG