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Immunobullous Disease Antibody Panel
Ordering Recommendation
Use for initial comprehensive testing to aid in the diagnosis and differentiation of skin and mucosal disorders that present with blistering, eczema, erosions, pruritus, and/or urticaria. Use to assess suspected epithelial antibody-associated immunobullous diseases (pemphigoid, pemphigus, and their variants), that are not clinically distinguishable, have nonspecific features, may express overlapping epithelial antibodies, and/or are indicated by concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572). Preferred panel to assess for epithelial antibodies as a side effect of immune checkpoint inhibitor (anti-PD-1, anti-PD-L1) therapy.
If dermatitis herpetiformis is suspected, order with Celiac Disease Reflexive Cascade, Serum (3016817) and Epidermal Transglutaminase (eTG/TG3) Antibody, IgA by ELISA (2010902).
For more information about components, methodology, and specimen type, refer to the ARUP Immunobullous Disease Testing Comparison tool.
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)
Refrigerated/ambient
Hemolyzed or lipemic specimens. Plasma.
As a general rule, serum specimens should be shipped to the laboratory as soon as possible. Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Methodology
Semi-Quantitative Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
Performed
Varies
Reported
3-9 days
Reference Interval
By report
Interpretive Data
Refer to report
Performed by non-ARUP Laboratory
Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.
Hotline History
CPT Codes
88346; 88350 x5; 83516 x5
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3001665 | Immunobullous Disease Panel | |
| 3001666 | EER Immunobullous Disease Panel |
Aliases
- atypical epithelial antibody-associated disease
- basement membrane zone antibody-associated disease
- Brunsting-Perry cicatricial pemphigoid
- Brunsting-Perry pemphigoid
- bullous disease of childhood
- bullous lupus erythematosus
- bullous pemphigoid
- bullous pemphigoid antigen 1 or BPAg1, BP230
- bullous pemphigoid antigen 2 or BPAg2, NC16A, BP180
- bullous systemic lupus erythematosus
- cell surface antibody-associated disease
- childhood immunobullous disease
- chronic bullous disease of childhood
- cicatricial pemphigoid
- collagen type 17
- collagen type XVII
- dermal basement membrane zone (floor) antibodies with split skin substrate
- desmoglein 1
- desmoglein 3
- desmosomal protein antibodies
- desmosome antibodies
- endemic pemphigus
- epidermolysis bullosa acquisita
- epithelial antibody-associated disease
- epithelial basement membrane zone antibody-associated disease
- epithelial cell surface antibody associated disease
- fogo selvagem
- hemidesmosomal protein antibodies
- hemidesmosome antibodies
- ICS antibodies
- IgA mucous membrane pemphigoid
- IgA pemphigus
- IgA variant epidermolysis bullosa acquisita (EBA)
- IgG pemphigus variant
- IgG variant pemphigus
- IgG/IgA basement membrane zone antibodies
- immunobullous disease of childhood
- Immunobullous Disease Panel, Epithelial
- indirect fluorescence assay
- indirect fluorescent antibody (IFA)
- indirect immunofluorescent assay
- intercellular IgG/IgA dermatosis
- intercellular substance antibodies
- intraepidermal neutrophilic IgA dermatosis
- linear IgA bullous dermatosis
- linear IgA disease
- linear IgAG/IgAG bullous dermatosis
- mixed epithelial antibody-associated disease
- mixed immunobullous disease of childhood
- mucous membrane pemphigoid
- ocular cicatricial pemphigoid
- pemphigoid variants
- pemphigus erythematosus
- pemphigus foliaceus
- pemphigus variant
- pemphigus vegetans
- pemphigus vulgaris
- salt split skin test
- salt-split skin floor antibodies
- salt-split skin roof antibodies
- subcorneal pustular dermatosis
- subepithelial immunobullous disease
- Type VII collagen antibodies, type XVII collagen
