Ordering Recommendation

Use as initial comprehensive testing panel to aid in the diagnosis of and distinguishing among skin and mucous membrane disorders that present with blistering, erosions, eczema, pruritus, and/or urticaria. Use for assessment of suspected epithelial antibody-associated immunobullous diseases, pemphigoid and pemphigus and their variants, that are not clinically distinguishable, have nonspecific features, potentially express overlapping epithelial antibodies, and/or are indicated by concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572).

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.


Semi-Quantitative Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)




4-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Plain Red or Serum Separator Tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma


Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory


For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History


CPT Codes

88346; 88350 x5; 83516 x5


Component Test Code* Component Chart Name LOINC
3001665 Immunobullous Disease Panel
3001666 EER Immunobullous Disease Panel
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • atypical epithelial antibody-associated disease
  • basement membrane zone antibody-associated disease
  • bullous disease of childhood
  • bullous lupus erythematosus
  • bullous pemphigoid
  • bullous pemphigoid antigen 1 or BPAg1
  • bullous pemphigoid antigen 2 or BPAg2
  • childhood immunobullous disease
  • cicatricial pemphigoid
  • collagen type 17
  • collagen type XVII
  • desmosomal protein antibodies
  • desmosome antibodies
  • endemic pemphigus
  • epidermolysis bullosa acquisita
  • epithelial antibody-associated disease
  • fogo selvagem
  • hemidesmosomal protein antibodies
  • ICS antibodies
  • IgA pemphigus
  • IgG/IgA basement membrane zone antibodies
  • Immunobullous Disease Panel, Epithelial
  • intercellular IgG/IgA dermatosis
  • intercellular substance antibodies
  • intraepidermal neutrophilic IgA dermatosis
  • linear IgA bullous dermatosis
  • linear IgA disease
  • linear IgG/IgA bullous dermatosis
  • mixed epithelial antibody-associated disease
  • mixed immunobullous disease of childhood
  • mucous membrane pemphigoid
  • NC16A
  • ocular cicatricial pemphigoid
  • pemphigoid variants
  • pemphigus erythematosus
  • pemphigus foliaceus
  • pemphigus vegetans
  • pemphigus vulgaris
  • salt split skin test
  • subcorneal pustular dermatosis
  • subepithelial immunobullous disease
  • type XVII collagen
Immunobullous Disease Antibody Panel