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Immunobullous Disease Antibody Panel
Ordering Recommendation
Use for initial comprehensive testing to aid in the diagnosis and differentiation of skin and mucosal disorders that present with blistering, eczema, erosions, pruritus, and/or urticaria. Use to assess suspected epithelial antibody-associated immunobullous diseases (pemphigoid, pemphigus, and their variants), that are not clinically distinguishable, have nonspecific features, may express overlapping epithelial antibodies, and/or are indicated by concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572). Preferred panel to assess for epithelial antibodies as a side effect of immune checkpoint inhibitor (anti-PD-1, anti-PD-L1) therapy.
If dermatitis herpetiformis is suspected, order with Celiac Disease Reflexive Cascade, Serum (3016817) and Epidermal Transglutaminase (eTG/TG3) Antibody, IgA by ELISA (2010902).
For more information about components, methodology, and specimen type, refer to the ARUP Immunobullous Disease Testing Comparison tool.
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)
Refrigerated/ambient
Hemolyzed or lipemic specimens. Plasma.
As a general rule, serum specimens should be shipped to the laboratory as soon as possible. Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Methodology
Semi-Quantitative Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
Performed
Varies
Reported
3-9 days
Reference Interval
By report
Interpretive Data
Refer to report
Performed by non-ARUP Laboratory
Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.
Hotline History
CPT Codes
88346; 88350 x5; 83516 x5
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3001665 | Immunobullous Disease Panel | |
| 3001666 | EER Immunobullous Disease Panel |
Aliases
- immunobullous disease of childhood
- Brunsting-Perry pemphigoid
- bullous disease of childhood
- bullous pemphigoid antigen 2 or BPAg2, NC16A, BP180
- hemidesmosome antibodies
- ICS antibodies
- intercellular IgG/IgA dermatosis
- intercellular substance antibodies
- intraepidermal neutrophilic IgA dermatosis
- epithelial cell surface antibody associated disease
- IgA pemphigus
- basement membrane zone antibody-associated disease
- Brunsting-Perry cicatricial pemphigoid
- bullous systemic lupus erythematosus
- cell surface antibody-associated disease
- collagen type 17
- collagen type XVII
- desmoglein 3
- epidermolysis bullosa acquisita
- pemphigus variant
- pemphigus vegetans
- childhood immunobullous disease
- epithelial antibody-associated disease
- fogo selvagem
- indirect fluorescence assay
- pemphigus foliaceus
- salt-split skin floor antibodies
- subcorneal pustular dermatosis
- Type VII collagen antibodies, type XVII collagen
- indirect fluorescent antibody (IFA)
- epithelial basement membrane zone antibody-associated disease
- hemidesmosomal protein antibodies
- Immunobullous Disease Panel, Epithelial
- atypical epithelial antibody-associated disease
- bullous pemphigoid antigen 1 or BPAg1, BP230
- salt-split skin roof antibodies
- desmoglein 1
- indirect immunofluorescent assay
- IgA variant epidermolysis bullosa acquisita (EBA)
- chronic bullous disease of childhood
- subepithelial immunobullous disease
- IgG pemphigus variant
- desmosomal protein antibodies
- desmosome antibodies
- endemic pemphigus
- IgG variant pemphigus
- cicatricial pemphigoid
- dermal basement membrane zone (floor) antibodies with split skin substrate
- linear IgA disease
- IgG/IgA basement membrane zone antibodies
- linear IgAG/IgAG bullous dermatosis
- mixed epithelial antibody-associated disease
- mixed immunobullous disease of childhood
- mucous membrane pemphigoid
- pemphigoid variants
- IgA mucous membrane pemphigoid
- ocular cicatricial pemphigoid
- pemphigus erythematosus
- linear IgA bullous dermatosis
- pemphigus vulgaris
- salt split skin test
- bullous lupus erythematosus
- bullous pemphigoid
