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Basement Membrane Zone Antibody Panel
Ordering Recommendation
Use as the preferred initial diagnostic panel for suspected basement membrane zone antibody-associated skin and mucous membrane disorders that present with blistering, erosions, eczema, urticaria, pruritus, and/or mucositis. May be indicated by concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572).
Alternatively, order the comprehensive Immunobullous Disease Antibody Panel (3001409) for initial serum diagnostic assessment of epithelial antibody-associated diseases, pemphigoid, pemphigus, and their variants.
For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.
New York DOH Approval Status
Specimen Required
Plain Red or Serum Separator Tube (SST).
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated/Ambient
Hemolyzed or lipemic specimens. Plasma
As a general rule, serum specimens should be shipped to the laboratory as soon as possible.
Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Methodology
Semi-Quantitative Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
Performed
Varies
Reported
3-9 days
Reference Interval
By report
Interpretive Data
Refer to report.
Performed by non-ARUP Laboratory
Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.
Hotline History
Hotline History
CPT Codes
88346; 88350 x3; 83516 x3
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3001664 | Basement Membrane Zone Ab Panel | 63566-4 |
| 3001667 | EER Basement Membrane Zone Ab Panel |
Aliases
- linear IgA bullous dermatosis
- salt-split skin test
- subepithelial immunobullous disease
- type VII collagen antibodies
- mucous membrane pemphigoid
- IgG/IgA basement membrane zone antibodies
- linear IgA disease
- linear IgA/IgG bullous dermatosis
- mixed immunobullous disease of childhood
- atypical epithelial antibody-associated disease
- basement membrane zone antibody-associated disease
- Brunsting-Perry cicatricial pemphigoid
- Brunsting-Perry pemphigoid
- bullous lupus erythematosus
- bullous pemphigoid
- bullous pemphigoid antigen 1 or BPAg1
- bullous pemphigoid antigen 2 or BPAg2, NC16A
- bullous systemic lupus erythematosus
- childhood immunobullous disease
- chronic bullous disease of childhood
- cicatricial pemphigoid
- collagen type 17
- collagen type XVII
- dermal basement membrane zone (floor) antibodies with split skin substrate
- epidermal basement membrane zone (roof) antibodies with split skin substrate
- epidermolysis bullosa acquisita (EBA)
- epithelial antibody-associated disease
- hemidesmosomal protein antibodies
- hemidesmosome antibodies
- IgA mucous membrane pemphigoid
- IgA variant epidermolysis bullosa acquisita (EBA)
- ocular cicatricial pemphigoid
- pemphigoid variants
- salt-split skin floor antibodies
- mixed epithelial antibody-associated disease
- immunobullous disease of childhood
- type XVII collagen, collagen type XVII
- salt-split skin roof antibodies
- indirect fluorescence assay
- indirect fluorescent antibody (IFA)
- indirect immunofluorescent assay
