Ordering Recommendation

Use as the preferred initial diagnostic panel for suspected basement membrane zone antibody-associated skin and mucous membrane disorders that present with blistering, erosions, eczema, urticaria, pruritus, and/or mucositis. May be indicated by concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572).

Alternatively, order the comprehensive Immunobullous Disease Antibody Panel (3001409) for initial serum diagnostic assessment of epithelial antibody-associated diseases, pemphigoid, pemphigus, and their variants.

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Plain Red or Serum Separator Tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma


Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely


Semi-Quantitative Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)




4-9 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory


For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History


CPT Codes

88346; 88350 x3; 83516 x3


Component Test Code* Component Chart Name LOINC
3001664 Basement Membrane Zone Ab Panel 63566-4
3001667 EER Basement Membrane Zone Ab Panel
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • basement membrane zone antibody-associated disease
  • bullous lupus erythematosus
  • bullous pemphigoid
  • bullous pemphigoid antigen 1 or BPAg1
  • bullous pemphigoid antigen 2 or BPAg2
  • childhood immunobullous disease
  • chronic bullous disease of childhood
  • cicatricial pemphigoid
  • collagen type 17
  • dermal basement membrane zone antibodies on split skin substrate
  • epidermal basement membrane zone antibodies on split skin substrate
  • epidermolysis bullosa acquisita (EBA)
  • hemidesmosomal protein antibodies
  • hemidesmosome antibodies
  • IgA variant epidermolysis bullosa acquisita (EBA)
  • IgG/IgA basement membrane zone antibodies
  • immunobullous disease of childhood
  • linear IgA bullous dermatosis (LABD)
  • linear IgA disease (LAD)
  • linear IgG/IgA bullous dermatosis; mixed immunobullous disease of childhood
  • mucous membrane pemphigoid
  • NC16A
  • ocular cicatricial pemphigoid
  • pemphigoid variants
  • salt-split skin floor antibodies
  • salt-split skin roof antibodies
  • salt-split skin test
  • subepithelial immunobullous disease
  • type VII collagen antibodies
  • type XVII collagen, collagen type XVII
Basement Membrane Zone Antibody Panel