Ordering Recommendation

Use as the preferred initial diagnostic panel for suspected basement membrane zone antibody-associated skin and mucous membrane disorders that present with blistering, erosions, eczema, urticaria, pruritus, and/or mucositis. May be indicated by concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572).

Alternatively, order the comprehensive Immunobullous Disease Antibody Panel (3001409) for initial serum diagnostic assessment of epithelial antibody-associated diseases, pemphigoid, pemphigus, and their variants.

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

Mnemonic

BMZ AB PAN

Methodology

Semi-Quantitative Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Varies

Reported

4-9 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Plain Red or Serum Separator Tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History

N/A

CPT Codes

88346; 88350 x3; 83516 x3

Components

Component Test Code* Component Chart Name LOINC
3001664 Basement Membrane Zone Ab Panel 63566-4
3001667 EER Basement Membrane Zone Ab Panel
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • basement membrane zone antibody-associated disease
  • bullous lupus erythematosus
  • bullous pemphigoid
  • bullous pemphigoid antigen 1 or BPAg1
  • bullous pemphigoid antigen 2 or BPAg2
  • childhood immunobullous disease
  • chronic bullous disease of childhood
  • cicatricial pemphigoid
  • collagen type 17
  • dermal basement membrane zone antibodies on split skin substrate
  • epidermal basement membrane zone antibodies on split skin substrate
  • epidermolysis bullosa acquisita (EBA)
  • hemidesmosomal protein antibodies
  • hemidesmosome antibodies
  • IgA variant epidermolysis bullosa acquisita (EBA)
  • IgG/IgA basement membrane zone antibodies
  • immunobullous disease of childhood
  • linear IgA bullous dermatosis (LABD)
  • linear IgA disease (LAD)
  • linear IgG/IgA bullous dermatosis; mixed immunobullous disease of childhood
  • mucous membrane pemphigoid
  • NC16A
  • ocular cicatricial pemphigoid
  • pemphigoid variants
  • salt-split skin floor antibodies
  • salt-split skin roof antibodies
  • salt-split skin test
  • subepithelial immunobullous disease
  • type VII collagen antibodies
  • type XVII collagen, collagen type XVII
Basement Membrane Zone Antibody Panel