Ordering Recommendation

• Preferred panel for initial assessment and disease monitoring in IgG-variant pemphigus. Pemphigus vulgaris and pemphigus foliaceus are the most common types of pemphigus with blistering and erosive disease affecting skin and mucous membranes.
• Panel components include antibody testing for IgG epithelial cell surface and IgG desmoglein 1 and 3. To order individual component tests, refer to Epithelial Skin Antibody (0090299) and/or Desmoglein 1 and Desmoglein 3 Antibodies in Pemphigus, IgG (0090649).
• To screen for pemphigus along with other possible immunobullous diseases, order concurrently with Basement Membrane Zone Antibody Panel (3001410); this panel includes IGA and IgG BMZ antibodies, BP180 and BP230 antibodies, IgG, and collagen VII antibodies, IgG. Also order with Pemphigus Antibody IgA (0092106), AND Cutaneous Direct Immunofluorescence, Biopsy (0092572).
• Alternatively, order Immunobullous Disease Panel, Epithelial (3001409), AND Cutaneous Direct Immunofluorescence, Biopsy (0092572). (Note that the Pemphigus Antibody Panel is included as part of the Immunobullous Disease Panel, Epithelial.)

Mnemonic
PEMPHI PAN
Methodology

Enzyme-Linked Immunosorbent Assay/Indirect Fluorescent Antibody

Performed

Varies

Reported

4-9 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plain red or serum separator tube.

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



No compliance statements are in use for this test.

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History
N/A
CPT Codes

88346; 88350; 83516 x2

Components
Component Test Code* Component Chart Name LOINC
0090651 Pemphigus Antibody Panel, IgG 21352-0
2010913 EER Pemphigus Antibody Panel, IgG 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG