Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (INACTIVE as of 11/15/21: Refer to 3004013 in the November Hotline)

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Clinical Information for Immunodermatology (Serum Testing)

Ordering Recommendation

Use as preferred serum antibody panel for initial assessment and disease monitoring in IgG-variant pemphigus. Testing should be clinically supported and/or correlated with concurrent Cutaneous Direct Immunofluorescence, Biopsy (0092572).

Pemphigus vulgaris and pemphigus foliaceus are the most common types of IgG-variant pemphigus with blistering and erosive disease affecting skin and mucous membranes.

Panel components include antibody testing for IgG epithelial cell surface and IgG desmoglein 1 and 3. To order individual component tests, refer to Epithelial Cell Surface Antibody IgG (0090266) or Epithelial Skin Antibody (0090299) and Desmoglein 1 and Desmoglein 3 Antibodies in Pemphigus, IgG (0090649).

To assess for pemphigus along with other immunobullous diseases, order concurrently with Basement Membrane Zone Antibody Panel (3001410). Also order with Pemphigus Antibody IgA (0092106).

Alternatively, order Immunobullous Disease Panel, Epithelial (3001409). Note that this test is included as part of the Immunobullous Disease Panel, Epithelial.

Mnemonic

PEMPHI PAN

Methodology

Semi-Quantitative Indirect Fluorescent Antibody (IFA)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Varies

Reported

4-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube.

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



Compliance Category

Not Applicable

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History

N/A

CPT Codes

88346; 88350; 83516 x2

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Components

Component Test Code* Component Chart Name LOINC
0090651 Pemphigus Antibody Panel, IgG 21352-0
2010913 EER Pemphigus Antibody Panel, IgG 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (INACTIVE as of 11/15/21: Refer to 3004013 in the November Hotline)