Pemphigus Antibody Panel, IgG

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Clinical Information for Immunodermatology (Serum Testing)

Ordering Recommendation

Use as the preferred serum antibody panel to assess and monitor IgG-variant pemphigus (includes pemphigus foliaceus and pemphigus vulgaris), which present with blistering and erosive disease affecting skin and mucous membranes. Testing should be correlated with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572).

To assess for other immunobullous diseases along with pemphigus, including the rare IgA pemphigus variant, order concurrently with serum Basement Membrane Zone Antibody Panel (3001410) and Pemphigus Antibodies, IgA by IIF (0092106). Alternatively, order Immunobullous Disease Antibody Panel (3001409).

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

Mnemonic

PEMPHI PAN

Methodology

Semi-Quantitative Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Varies

Reported

3-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Plain Red or Serum Separator Tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
11/14/2022
X
X
X
X
X
N/A

CPT Codes

88346; 88350; 83516 x2

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Components

Component Test Code* Component Chart Name LOINC
0090651 Pemphigus Antibody Panel, IgG 21352-0
2010913 EER Pemphigus Antibody Panel, IgG 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • desmosomal protein antibodies
  • desmosome antibodies
  • endemic pemphigus
  • fogo selvagem
  • ICS antibodies
  • intercellular IgG/IgA dermatosis
  • intercellular substance antibodies
  • Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Anti
  • pemphigus erythematosus
  • pemphigus foliaceus
  • pemphigus vegetans
  • pemphigus vulgaris
Pemphigus Antibody Panel, IgG