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Glutamic Acid Decarboxylase Antibody
2001771
Ordering Recommendation

Most useful to establish autoimmune etiology in previously diagnosed type 1 diabetes mellitus (DM). Do not use to differentiate type 1 DM from type 2 DM, for most cases.
If pursuing antibody testing to determine autoimmune DM, perform at least two antibody tests. In most cases, use glutamic acid decarboxylase antibody in combination with another antibody test. Other antibody tests include Insulin Antibody (0099228), Islet Cell Cytoplasmic Antibody, IgG (0050138), and Zinc Transporter 8 Antibody (2006196).

Mnemonic
GAD-AB
Methodology
Semi-quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Fri
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. 
Specimen Preparation
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
Plasma. Grossly hemolyzed specimens. 
Remarks
 
Stability
Ambient: 24 hours; Refrigerated: 1 week; Frozen: 3 months 
Reference Interval
0.0-5.0 IU/mL
Interpretive Data
A value greater than 5.0 IU/mL is considered positive for Glutamic Acid Decarboxylase Antibody (GAD Ab).

This assay is intended for the semi-quantitative determination of the GAD Ab in human serum. Results should be interpreted within the context of clinical symptoms.

Note
Hotline History
View Hotline History
CPT Code(s)
86341
Components
Component Test Code*Component Chart NameLOINC
2001772Glutamic Acid Decarboxylase Antibody56540-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 64K Antibody
  • Anti-GAD Antibodies
  • Anti-Glutamic Acid Decarboxylase Ab
  • Beta Cell Antibody
  • Beta-Cell Autoantibody to GAD 65
  • GAD Antibody
  • GAD-65
  • GAD65
  • GAD65 Antibody Assay
  • Glutamate Decarboxylase Antibodies
  • Pancreatic Islet Cell Ab