Ordering Recommendation

Most useful to establish autoimmumne etiology in previously diagnosed type 1 diabetes mellitus (DM). Do not use to differentiate type 1 DM from type 2 DM, for most cases.
If pursuing antibody testing to determine autoimmune DM, perform at least two antibody tests. In most cases, use glutamic acid decarboxylase antibody in combination with another antibody test. Other antibody tests include Glutamic Acid Decarboxylase Antibody (2001771), Insulin Antibody (0099228), and Islet Cell Cytoplasmic Antibody, IgG (0050138).

Mnemonic
ZNT8 AB
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Wed

Reported

1-8 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube or plain red.

Specimen Preparation

Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma. Grossly hemolyzed or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 5 days; Refrigerated: 1 week; Frozen: 3 months

Reference Interval

0.0-15.0 Kronus Units/mL

Interpretive Data

A value greater than 15.0 Kronus Units/mL is considered positive for Zinc Transporter 8 antibody( ZnT8 ).
Kronus Units are arbitrary. Kronus Units = U/mL. This assay is intended for the semi-quantitative determination of antibodies to ZnT8 in human serum. Results should be interpreted within the context of clinical symptoms.

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

86341

Components
Component Test Code* Component Chart Name LOINC
2006197 Zinc Transporter 8 Antibody 76651-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ZnT8
  • ZnT8 antibodies
  • ZnT8A
Zinc Transporter 8 Antibody