Islet Antigen-2 (IA-2) Autoantibody, Serum

3001499
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Additional Technical Information

Ordering Recommendation

If pursuing antibody testing to determine autoimmune diabetes mellitus, perform at least two antibody tests. In most cases, use glutamic acid decarboxylase antibody in combination with another antibody test. Other antibody tests include Glutamic Acid Decarboxylase Antibody (2001771), Insulin Antibody (0099228), Islet Cell Cytoplasmic Antibody, IgG (0050138), and Zinc Transporter 8 Antibody (2006196). Most useful to establish autoimmune etiology in previously diagnosed type 1 DM. Do not use to differentiate type 1 DM from type 2 DM, for most cases.
 

Mnemonic

IA-2 AB

Methodology

Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Mon, Wed, Fri

Reported

2-10 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Plain Red or Serum Separator Tube (SST).

Specimen Preparation

Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.35 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma. Specimens submitted in frozen Serum Separator Tubes (SST). Grossly hemolyzed, icteric, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 2 months

Reference Interval

0.0-7.4 Units/mL

Interpretive Data

A value greater than or equal to 7.5 Units/mL is considered positive for IA-2 autoantibody.

This assay is intended for the quantitative determination of autoantibodies to Islet Antigen-2 (IA-2) in human serum. Results should be interpreted within the context of clinical symptoms.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

86341

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Components

Component Test Code* Component Chart Name LOINC
3001500 IA-2, Autoantibody 56718-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Anti-IA2 Antibody
  • IA-2
  • IA-2 AB
  • IA-2 Autoantibody
  • ICA-512
  • Islet Antigen 2
  • Islet Cell Antibody
  • Islet Cell Antigen (ICA) 512
  • Tyrosine Phosphatase-Like Protein Antibodies
  • tyrosine phosphatase-related islet antigen 2
Islet Antigen-2 (IA-2) Autoantibody, Serum