Ordering Recommendation

Aids in diagnosis of stiff-person syndrome, limbic encephalitis, and other autoimmune neurologic disorders. May be used in monitoring treatment response in individuals who are antibody positive. For analysis in serum, refer to Glutamic Acid Decarboxylase Antibody (2001771).

Mnemonic
GAD AB CSF
Methodology

Semi-quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun-Fri

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Cerebral Spinal Fluid (CSF)

Specimen Preparation

Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Frozen

Unacceptable Conditions

Fluid other than CSF. Grossly hemolyzed specimens.

Remarks
Stability

Ambient: 24 hours; Refrigerated: 1 week; Frozen: 3 months

Reference Interval

0.0-5.0 IU/mL

Interpretive Data

A value greater than 5.0 IU/mL is considered positive for glutamic acid decarboxylase antibody (GAD AB CSF).

This assay is intended for the semi-quantitative determination of the GAD Ab in human CSF. Results should be interpreted within the context of clinical symptoms.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

86341

Components
Component Test Code* Component Chart Name LOINC
3002789 Glutamic Acid Decarboxylase Antibody CSF 42501-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 64K Antibody
  • Anti-GAD Antibodies
  • Anti-Glutamic Acid Decarboxylase Ab
  • Beta Cell Antibody
  • Beta-Cell Autoantibody to GAD 65
  • GAD Antibody
  • GAD CSF
  • GAD Spinal Fluid
  • GAD-65
  • GAD65
  • GAD65 Antibody Assay
  • Glutamate Decarboxylase Antibodies
  • Glutamic Acid Decarboxylase CSF
  • Glutamic Acid Decarboxylase Spinal Fluid
  • Pancreatic Islet Cell Ab
Glutamic Acid Decarboxylase Antibody, CSF