Ordering Recommendation

Use as preferred panel to assess and monitor patient with possible pemphigoid gestationis (herpes gestationis) or other immunobullous disease with complement-fixing basement membrane zone antibodies. Testing should be clinically supported and/or correlated with concurrent Cutaneous Direct Immunofluorescence, Biopsy (0092572).

Pemphigoid gestationis is a rare disease of pregnancy; consider other types of immunobullous disease testing concurrently (ie, Epithelial Basement Membrane Zone Antibody IgA [0092057], Collagen Type VII Antibody IgG by ELISA [2010905], and/or Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG [0090650]).

Mnemonic
HG FACTOR
Methodology

Semi-quantitative Immunofluorescence/Enzyme-Linked Immunosorbent Assay

Performed

Varies

Reported

5-8 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



No compliance statements are in use for this test.

Note

The methodology is indirect immunofluorescence (IFA) of serum on human split skin substrate for detection of complement-fixing (herpes gestationis factor) and non-complement-fixing IgG basement membrane zone antibodies. For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History
N/A
CPT Codes

88346; 88350 x3; 83516

Components
Component Test Code* Component Chart Name LOINC
0092284 Herpes Gestationis Factor Ab IgG 45179-9
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Aliases
Herpes Gestationis Factor (Complement-Fixing Basement Membrane Zone Antibody IgG)