Pemphigoid Gestationis, Complement-Fixing Basement Membrane Antibodies (Herpes Gestationis Factor)
Use as the preferred panel to assess and monitor pemphigoid gestationis (herpes gestationis) or other immunobullous disease with complement-fixing basement membrane zone antibodies. Testing should be correlated with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572).
Consider other types of immunobullous disease serum testing concurrently such as Basement Membrane Zone (Epithelial) Antibodies, IgA by IIF (0092057), Collagen Type VII Antibody, IgG by ELISA (2010905), and/or Pemphigus Antibody Panel, IgG (0090650). Alternatively, order concurrently with Immunobullous Disease Antibody Panel (3001409) for broad, comprehensive immunobullous disease testing.
For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.
Semi-Quantitative Complement Fixation/Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
New York DOH Approval Status
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)
Hemolyzed or lipemic specimens. Plasma.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Refer to report
Performed by non-ARUP Laboratory
The methodology is indirect immunofluorescence (IIF) with added fresh human complement on human split skin substrate for detection of complement-fixing (herpes gestationis factor) and noncomplement-fixing IgG basement membrane zone antibodies together with IgG BP180 antibody level determination by ELISA in serum. For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
88346; 88350 x3; 83516
|Component Test Code*||Component Chart Name||LOINC|
|0092284||Herpes Gestationis Factor Ab IgG||45179-9|
- basement membrane zone antibodies in pregnancy
- basement membrane zone antibody-associated disease
- bullous pemphigoid antigen 2 or BPAg2
- collagen type 17
- collagen type XVII
- hemidesmosomal protein antibodies
- hemidesmosome antibodies
- Herpes Gestationis Factor (Complement-Fixing Basement Membrane Zone Antibody IgG)
- IgG BP 180
- pemphigoid variants
- salt-split skin test
- subepithelial immunobullous disease
- type XVII collagen