Ordering Recommendation

Use as the preferred panel to assess and monitor pemphigoid gestationis (herpes gestationis) or other immunobullous disease with complement-fixing basement membrane zone antibodies. Testing should be correlated with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572). 

Consider other types of immunobullous disease serum testing concurrently such as Basement Membrane Zone (Epithelial) Antibodies, IgA by IIF (0092057), Collagen Type VII Antibody, IgG by ELISA (2010905), and/or Pemphigus Antibody Panel, IgG (0090650). Alternatively, order concurrently with Immunobullous Disease Antibody Panel (3001409) for broad, comprehensive immunobullous disease testing.

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature


Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.


Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely


Semi-Quantitative Complement Fixation/Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)




5-8 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory


The methodology is indirect immunofluorescence (IIF) with added fresh human complement on human split skin substrate for detection of complement-fixing (herpes gestationis factor) and noncomplement-fixing IgG basement membrane zone antibodies together with IgG BP180 antibody level determination by ELISA in serum. For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History


CPT Codes

88346; 88350 x3; 83516


Component Test Code* Component Chart Name LOINC
0092284 Herpes Gestationis Factor Ab IgG 45179-9
3004039 EER Herpes Gestationis Factor Ab IgG 45179-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • basement membrane zone antibodies in pregnancy
  • basement membrane zone antibody-associated disease
  • bullous pemphigoid antigen 2 or BPAg2
  • collagen type 17
  • collagen type XVII
  • hemidesmosomal protein antibodies
  • hemidesmosome antibodies
  • Herpes Gestationis Factor (Complement-Fixing Basement Membrane Zone Antibody IgG)
  • HGF
  • IgG BP 180
  • NC16A
  • pemphigoid variants
  • pregnancy
  • puerperium
  • salt-split skin test
  • subepithelial immunobullous disease
  • type XVII collagen
Pemphigoid Gestationis, Complement-Fixing Basement Membrane Antibodies (Herpes Gestationis Factor)