Ordering Recommendation

Use as preferred panel to assess and monitor patient with possible pemphigoid gestationis (herpes gestationis) or other immunobullous disease with complement-fixing basement membrane zone antibodies. Testing should be clinically supported and/or correlated with concurrent Cutaneous Direct Immunofluorescence, Biopsy (0092572).

Pemphigoid gestationis is a rare disease of pregnancy; consider other types of immunobullous disease testing concurrently (ie, Epithelial Basement Membrane Zone Antibody IgA [0092057], Collagen Type VII Antibody IgG by ELISA [2010905], and/or Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG [0090650]).

Mnemonic
HG FACTOR
Methodology

Semi-Quantitative Complement Fixation/Indirect Fluorescent Antibody (IFA)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Varies

Reported

5-8 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



Compliance Category

Not Applicable

Note

The methodology is indirect immunofluorescence (IFA) of serum on human split skin substrate for detection of complement-fixing (herpes gestationis factor) and non-complement-fixing IgG basement membrane zone antibodies. For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History
N/A
CPT Codes

88346; 88350 x3; 83516

Components
Component Test Code* Component Chart Name LOINC
0092284 Herpes Gestationis Factor Ab IgG 45179-9
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Aliases
Herpes Gestationis Factor (Complement-Fixing Basement Membrane Zone Antibody IgG)