Optimal specimen location and complementary serum testing and/or histopathology examination vary according to disease type. Specimen must be labeled with the acceptable transport medium used (eg, Michel’s or Zeus).
Perilesional specimen is recommended for blisters and/or erosions, proximal anatomical location for pemphigoid. Use with serum immunobullous disease/epithelial antibody testing and formalin-fixed tissue histopathology for assessment of pruritic, urticarial, blistering, and/or erosive disorders (eg, immunobullous diseases with or without blistering including pemphigoid and pemphigoid variants, pemphigus and pemphigus subtypes, linear lgA disease, dermatitis herpetiformis, epidermolysis bullous acquisita, porphyria, and pseudoporphyria).
Newly developed lesional specimen of intact skin or mucous membrane is recommended with formalin-fixed tissue histopathology for assessment of inflammatory, immune-mediated cutaneous disease (including possible lupus and lupus variants, vasculitis, drug reactions, lichen planus and other lichenoid reactions).
New York DOH Approval Status
Tissue: skin, mucosa (oral, conjunctival, genital, esophageal), other epithelium (gastrointestinal, respiratory, urinary).
Transport tissue (optimal 4-6 mm) in Michel's medium (ARUP supply #45462) available online through eSupply using ARUP Connector call ARUP Client Services at (800) 522-2787. Also acceptable: Zeus tissue fixative. Label container with transport medium type, if not an ARUP-supplied vial.
Room temperature. Also acceptable: Refrigerated.
Formalin-fixed tissue. Solid organs or solid organ tissue. Tissue in container of unknown or unacceptable transport medium.
Ambient: 10 days; Refrigerated: 10 days; Frozen: Unacceptable
Performed by non-ARUP Laboratory
88346; 88350 x5
|Component Test Code*||Component Chart Name||LOINC|
|0092571||Cutaneous Direct IF, Biopsy||6471-7|
|2010916||EER Cutaneous Direct IF, Biopsy|
- Bullous Disease
- Chronic Bullous Disease
- Cutaneous Herpetiformis
- Dermatitis Herpetiformis
- Lichen Planus and Lichenoid
- Linear IgA Bullous, Tissue
- Lupus Erythematous, Tissue
- Pemphigoid, Tissue
- Porphyria and Pseudoporphyria, Tissue
- Skin Immunofluorescence
- Urticarial Pemphigoid
- Urticarial Vasculitis