0092572
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Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial)

CUTDIF
Example Reports
Enhanced Report
Negative
Positive

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Clinical Information for Immunodermatology (Tissue Testing)

Ordering Recommendation

Use with serum immunobullous disease/epithelial antibody testing and separate formalin-fixed tissue histopathology for assessment of pruritic, urticarial, blistering, and/or erosive disorders. Use with separate formalin-fixed tissue histopathology for assessment of inflammatory, immune-mediated cutaneous disease.

Optimal specimen location and complementary serum testing and/or histopathology examination vary according to disease type. Note that specimen location and transport medium/fixative are different for direct immunofluorescence testing and fixed-tissue histopathology.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Tissue: skin, mucosa (oral, conjunctival, genital, esophageal), other epithelium (gastrointestinal, respiratory, urinary).

Specimen Preparation

Transport tissue (optimal 4-6 mm) in Michel's medium (ARUP supply #45462) available online through eSupply using ARUP Connect™ or call ARUP Client Services at 800-522-2787. Also acceptable: Zeus tissue fixative. Label container with transport medium type, if not an ARUP-supplied vial.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated.

Unacceptable Conditions

Formalin-fixed tissue. Frozen in Michel's medium. Solid organs or solid organ tissue. Tissue in container of unknown or unacceptable transport medium. Tissue sections on slides, prestained or unstained.

Remarks
Stability

Ambient: 10 days; Refrigerated: 10 days; Frozen: Unacceptable

Methodology

Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial)

Performed

Varies

Reported

3-9 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
01/21/2025
X
N/A

CPT Codes

88346; 88350 x5

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Components

Component Test Code* Component Chart Name LOINC
0092571 Cutaneous Direct IF, Biopsy 6471-7
2010916 EER Cutaneous Direct IF, Biopsy
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • mixed epithelial antibody-associated disease
  • mixed immunobullous disease of childhood
  • pemphigoid variants
  • subepithelial immunobullous disease
  • lichen planus
  • urticaria
  • pemphigus foliaceus
  • childhood immunobullous disease
  • cutaneous lupus
  • cell surface antibody-associated disease
  • pemphigus erythematosus
  • pemphigoid gestationis
  • bullous disease
  • chronic bullous disease of childhood
  • cicatricial pemphigoid
  • lichenoid reaction
  • Brunsting-Perry pemphigoid
  • Lupus Erythematous, Tissue
  • pemphigus variant
  • porphyria, pseudoporphyria tissue
  • linear IgA bullous dermatosis
  • skin immunofluorescence
  • subacute cutaneous lupus erythematosus
  • mucous membrane pemphigoid
  • ocular cicatricial pemphigoid
  • pemphigus vegetans
  • pemphigus vulgaris
  • pemphigus, tissue
  • immunobullous disease of childhood
  • intercellular IgG/IgA dermatosis
  • urticarial vasculitis
  • vasculitis
  • bullous pemphigoid
  • bullous systemic lupus erythematosus
  • IgG/IgA basement membrane zone antibodies
  • chronic bullous disease
  • bullous disease of childhood
  • bullous lupus erythematosus
  • lupus erythematosus
  • IgG pemphigus variant
  • IgG variant pemphigus
  • Cutaneous Direct Immunofluorescence, Biopsy
  • cutaneous herpetiformis
  • dermal basement membrane zone (floor) antibodies with split skin substrate
  • dermatitis herpetiformis
  • DIF
  • drug hypersensitivity
  • drug reaction
  • endemic pemphigus
  • epidermolysis bullosa acquisita
  • epithelial antibody-associated disease
  • epithelial basement membrane zone antibody-associated disease
  • epithelial cell surface antibody associated disease
  • fogo selvagem
  • gluten rash
  • Henoch-Schönlein purpura
  • herpetiformis
  • hypocomplementemic urticarial vasculitis
  • ICS antibodies
  • IgA mucous membrane pemphigoid
  • IgA pemphigus
  • IgA variant epidermolysis bullosa acquisita (EBA)
  • IgA vasculitis
  • immune-mediated vasculitis
  • intercellular substance antibodies
  • intraepidermal neutrophilic IgA dermatosis
  • leukocytoclastic vasculitis
  • Linear IgA Bullous, Tissue
  • porphyria and pseudoporphyria, tissue
  • linear IgA disease
  • linear IgG/IgA bullous dermatosis
  • Pemphigus
  • subcorneal pustular dermatosis
  • urticarial pemphigoid
  • vasculopathy
  • pemphigoid, tissue
  • celiac rash
  • lupus
  • basement membrane zone antibody-associated disease
  • Brunsting-Perry cicatricial pemphigoid
  • atypical epithelial antibody-associated disease
Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial)