Use with serum antibody testing and formalin-fixed tissue histopathology for assessment of pruritic, urticarial, blistering, and/or erosive disorders (immunobullous diseases with or without blistering including pemphigoid and pemphigoid variants, pemphigus and pemphigus subtypes, linear IgA disease, dermatitis herpetiformis, epidermolysis bullous acquisita, porphyria, and pseudoporphyria). Perilesional specimen is recommended for blisters and/or erosions; proximal anatomical location is recommended for pemphigoid.
Use with formalin-fixed tissue histopathology for assessment of inflammatory, immune-mediated cutaneous disease (including possible lupus and lupus variants, vasculitis, drug reactions, lichen planus and other lichenoid reactions). Newly developed lesional specimen of intact skin or mucous membrane is recommended.
Optimal specimen location varies according to disease type (ie, blistering or nonblistering).
New York DOH Approval Status
Tissue: skin, mucosa (oral, conjunctival, genital, esophageal), other epithelium (gastrointestinal, respiratory, urinary).
Transport tissue (optimal 4-6 mm) in Michel's medium (ARUP supply #45462) available online through eSupply using ARUP Connect or call ARUP Client Services at (800) 522-2787. Also acceptable: Zeus tissue fixative.
Room temperature. Also acceptable: Refrigerated.
Formalin-fixed tissue. Solid organs or solid organ tissue.
Ambient: 10 days; Refrigerated: 10 days; Frozen: Unacceptable
88346; 88350 x5
|Component Test Code*||Component Chart Name||LOINC|
|0092571||Cutaneous Direct IF, Biopsy||6471-7|
|2010916||EER Cutaneous Direct IF, Biopsy|
- Bullous Disease
- Chronic Bullous Disease
- Cutaneous Herpetiformis
- Dermatitis Herpetiformis
- Lichen Planus and Lichenoid
- Linear IgA Bullous, Tissue
- Lupus Erythematous, Tissue
- Pemphigoid, Tissue
- Porphyria and Pseudoporphyria, Tissue
- Skin Immunofluorescence
- Urticarial Pemphigoid
- Urticarial Vasculitis