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Epithelial Basement Membrane Zone Antibody IgA
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Ordering Recommendation
Use to assess and monitor positive IgA basement membrane zone antibodies, including epidermal (roof) pattern, dermal (floor) pattern, and combined on split skin substrate in patients with linear IgA disease, including linear IgA bullous dermatosis and chronic bullous disease of childhood, IgA variant epidermolysis bullosa acquisita (EBA), and overlap expression in pemphigoid with IgG basement membrane zone antibodies. Testing should be clinically supported and/or correlated with concurrent Cutaneous Direct Immunofluorescence, Biopsy (0092572).
Consider ordering concurrently with Epithelial Basement Membrane Zone Antibody IgG (0092056), Bullous Pemphigoid Antigens (180 kDa and 230 kDa), IgG (0092566), and Collagen Type VII Antibody IgG by ELISA (2010905); alternatively order Basement Membrane Zone Antibody Panel (3001410) or Immunobullous Disease Panel, Epithelial (3001409).
For initial linear IgA disease diagnosis, Basement Membrane Zone Antibody Panel (3001410) or Immunobullous Disease Panel, Epithelial (3001409) is preferred.
Mnemonic
Methodology
Semi-Quantitative Indirect Fluorescent Antibody (IFA)
Performed
Varies
Reported
4-9 days
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Hemolyzed or lipemic specimens.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Reference Interval
By report
Interpretive Data
Not Applicable
Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
Hotline History
CPT Codes
88346; 88350
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0092057 | Epithelial BMZ Ab, IgA |
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