Ordering Recommendation

Use to assess and monitor positive IgA basement membrane zone antibodies, including epidermal (roof) pattern, dermal (floor) pattern, and combined on split skin substrate in patients with linear IgA disease, including linear IgA bullous dermatosis and chronic bullous disease of childhood, IgA variant epidermolysis bullosa acquisita (EBA), and overlap expression in pemphigoid with IgG basement membrane zone antibodies. Testing should be clinically supported and/or correlated with concurrent Cutaneous Direct Immunofluorescence, Biopsy (0092572).

Consider ordering concurrently with Epithelial Basement Membrane Zone Antibody IgG (0092056), Bullous Pemphigoid Antigens (180 kDa and 230 kDa), IgG (0092566), and Collagen Type VII Antibody IgG by ELISA (2010905); alternatively order Basement Membrane Zone Antibody Panel (3001410) or Immunobullous Disease Panel, Epithelial (3001409).

For initial linear IgA disease diagnosis, Basement Membrane Zone Antibody Panel (3001410) or Immunobullous Disease Panel, Epithelial (3001409) is preferred.

Mnemonic
EBMZ IGA
Methodology

Semi-Quantitative Indirect Fluorescent Antibody (IFA)

Performed

Varies

Reported

4-9 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



No compliance statements are in use for this test.

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History
N/A
CPT Codes

88346; 88350

Components
Component Test Code* Component Chart Name LOINC
0092057 Epithelial BMZ Ab, IgA
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Epithelial Basement Membrane Zone Antibody IgA