Basement Membrane Zone (Epithelial) Antibodies, IgA by IIF
Ordering Recommendation
Use to assess and monitor IgA basement membrane zone antibodies in patients with linear IgA disease, including linear IgA bullous dermatosis and chronic bullous disease of childhood, and IgA variant epidermolysis bullosa acquisita (EBA). Testing should be correlated with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572).
For initial linear IgA disease diagnosis, serum Basement Membrane Zone Antibody Panel (3001410) or Immunobullous Disease Antibody Panel (3001409) is preferred and offers a more comprehensive evaluation.
For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)
Refrigerated: Ambient
Hemolyzed or lipemic specimens. Plasma.
As a general rule, serum specimens should be shipped to the laboratory as soon as possible.
Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Methodology
Semi-Quantitative Indirect Immunofluorescence (IIF)
Performed
Varies
Reported
4-9 days
Reference Interval
By report
Interpretive Data
Refer to report
Performed by non-ARUP Laboratory
Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.
Hotline History
Hotline History
CPT Codes
88346; 88350
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0092057 | Epithelial BMZ Ab, IgA | |
3004035 | EER Epithelial BMZ Ab, IgA | 38440-4 |
Aliases
- atypical epithelial antibody-associated disease
basement membrane zone antibody-associated disease
childhood immunobullous disease
chronic bullous disease of childhood
epithelial antibody-associated disease
Epithelial Basement Membrane Zone Antibody IgA
hemidesmosomal protein antibodies
hemidesmosome antibodies
IgA variant epidermolysis bullosa acquisita (EBA)
IgG/IgA basement membrane zone antibodies
immunobullous disease of childhood
indirect fluorescence assay
indirect fluorescent antibody (IFA)
indirect immunofluorescent assay
linear IgA bullous dermatosis
linear IgA disease
linear IgG/IgA bullous dermatosis
mixed epithelial antibody-associated disease
mixed immunobullous disease of childhood
salt-split skin test
subepithelial immunobullous disease