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Pemphigoid Antibody Panel
Ordering Recommendation
Use to assess and monitor pemphigoid, pemphigoid variants, and linear IgA disease and to discriminate among the immunobullous diseases with epithelial basement membrane zone antibodies. May be indicated by concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572). Preferred initial diagnostic serum panel is Basement Membrane Zone Antibody Panel (3001410).
Bullous pemphigoid and other pemphigoid variants, epidermolysis bullosa acquisita (EBA), linear IgA disease, and dermatitis herpetiformis may present with similar clinical findings including blistering, erosions, pruritus, and urticaria, which affect skin and mucous membranes.
To assess for other immunobullous diseases with diagnostic serum epithelial antibodies in addition to pemphigoid, order concurrently with Pemphigus Antibody Panel, IgG (0090650) and Collagen Type VII Antibody, IgG by ELISA (2010905). Alternatively, order Immunobullous Disease Antibody Panel (3001409).
For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube.
Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)
Refrigerated/Ambient
Hemolyzed or lipemic specimens. Plasma.
As a general rule, serum specimens should be shipped to the laboratory as soon as possible.
Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Methodology
Semi-Quantitative Indirect Immunofluorescence (IIF) / Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
Performed
Varies
Reported
3-9 days
Reference Interval
By report
Interpretive Data
Refer to report.
Performed by non-ARUP Laboratory
Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.
Hotline History
Hotline History
CPT Codes
88346; 88350 x3; 83516 x2
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0092002 | Pemphigoid Antibody Panel | 48767-8 |
| 2010914 | EER Pemphigoid Antibody Panel | 11526-1 |
Aliases
- atypical epithelial antibody-associated disease
basement membrane zone antibody-associated disease
Brunsting-Perry cicatricial pemphigoid
Brunsting-Perry pemphigoid
bullous lupus erythematosus
Bullous Pemphigoid
bullous pemphigoid antigen 1 or BPAg1
bullous pemphigoid antigen 2 or BPAg2, NC16A
bullous systemic lupus erythematosus
childhood immunobullous disease
chronic bullous disease of childhood
cicatricial pemphigoid
collagen type 17
collagen type XVII
dermal basement membrane zone (floor) antibodies with split skin substrate
epidermal basement membrane zone (roof) antibodies with split skin substrate
epidermolysis bullosa acquisita (EBA)
epithelial antibody-associated disease
hemidesmosomal protein antibodies
hemidesmosome antibodies
IgA mucous membrane pemphigoid
IgA variant epidermolysis bullosa acquisita (EBA)
IgG/IgA basement membrane zone antibodies
immunobullous disease of childhood
indirect fluorescence assay
indirect fluorescent antibody (IFA)
indirect immunofluorescent assay
linear IgA bullous dermatosis
linear IgA disease
linear IgA/IgG bullous dermatosis
mixed epithelial antibody-associated disease
mixed immunobullous disease of childhood
mucous membrane pemphigoid
ocular cicatricial pemphigoid
Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies, lgG and lgA, BP180 and BP230
pemphigoid variants
salt-split skin floor antibodies
salt-split skin roof antibodies
salt-split skin test
subepithelial immunobullous disease
type XVII collagen
