Ordering Recommendation

Use to assess and monitor pemphigoid, pemphigoid variants, and linear IgA disease and to discriminate among the immunobullous diseases with epithelial basement membrane zone antibodies. May be indicated by concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572). Preferred initial diagnostic serum panel is Basement Membrane Zone Antibody Panel (3001410).

Bullous pemphigoid and other pemphigoid variants, epidermolysis bullosa acquisita (EBA), linear IgA disease, and dermatitis herpetiformis may present with similar clinical findings including blistering, erosions, pruritus, and urticaria, which affect skin and mucous membranes.

To assess for other immunobullous diseases with diagnostic serum epithelial antibodies in addition to pemphigoid, order concurrently with Pemphigus Antibody Panel, IgG (0090650) and Collagen Type VII Antibody, IgG by ELISA (2010905). Alternatively, order Immunobullous Disease Antibody Panel (3001409).

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube.

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Methodology

Semi-Quantitative Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Varies

Reported

4-9 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History

N/A

CPT Codes

88346; 88350 x3; 83516 x2

Components

Component Test Code* Component Chart Name LOINC
0092002 Pemphigoid Antibody Panel 48767-8
2010914 EER Pemphigoid Antibody Panel 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • basement membrane zone antibody-associated disease
  • bullous disease of childhood
  • bullous lupus erythematosus
  • Bullous Pemphigoid
  • bullous pemphigoid antigen 1 or BPAg1
  • bullous pemphigoid antigen 2 or BPAg2
  • childhood immunobullous disease
  • chronic bullous disease of childhood
  • cicatricial pemphigoid
  • collagen type 17
  • collagen type XVII
  • dermal basement membrane zone antibodies on split skin substrate
  • epidermal basement membrane zone antibodies on split skin substrate
  • epidermolysis bullosa acquisita
  • hemidesmosomal protein antibodies
  • hemidesmosome antibodies
  • IgA variant epidermolysis bullosa acquisita (EBA)
  • IgG/IgA basement membrane zone antibodies
  • immunobullous disease of childhood
  • linear IgA bullous dermatosis
  • linear IgA disease
  • linear IgG/IgA bullous dermatosis
  • mixed immunobullous disease of childhood
  • mucous membrane pemphigoid
  • NC16A
  • ocular cicatricial pemphigoid
  • Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies, IgG and IgA, BP180 and BP2
  • pemphigoid variants
  • salt-split skin floor antibodies
  • salt-split skin roof antibodies
  • salt-split skin test
  • subepithelial immunobullous disease
  • type XVII collagen
Pemphigoid Antibody Panel