Ordering Recommendation

Use as antibody panel for initial assessment of and disease monitoring in pemphigoid and linear IgA bullous dermatosis and to discriminate among the immunobullous skin diseases with epithelial basement membrane zone antibodies. Testing should be clinically supported and/or correlated with concurrent Cutaneous Direct Immunofluorescence, Biopsy (0092572).

Bullous pemphigoid and other pemphigoid variants, epidermolysis bullosa acquisita (EBA), and linear IgA bullous dermatosis present with similar clinical findings including blistering, erosions, pruritus, and urticaria, which affect skin and mucous membranes.

Panel components include IgG and IgA epithelial basement membrane zone antibodies and IgG bullous pemphigoid BP 180 and 230 antigens. To order individual component tests, refer to Epithelial Basement Membrane Zone Antibody IgG (0092056), Epithelial Basement Membrane Zone Antibody IgA (0092057), and Bullous Pemphigoid Antigens (180 kDa and 230 kDa), IgG (0092566).

Preferred panel is Basement Membrane Zone Antibody Panel (3001410), which also includes testing for EBA with the Collagen Type VII Antibody IgG by ELISA.

To assess for pemphigoid and other immunobullous diseases with epithelial antibodies, order concurrently with Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650), and Collagen Type VII Antibody IgG by ELISA (2010905).

Alternatively, order Immunobullous Disease Panel, Epithelial (3001409). Note that this test is included as part of the Immunobullous Disease Panel, Epithelial.

Mnemonic
PGOID PAN
Methodology

Semi-Quantitative Indirect Fluorescent Antibody (IFA)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Varies

Reported

4-9 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plain red or serum separator tube.

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



Compliance Category

Not Applicable

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History
N/A
CPT Codes

88346; 88350 x2; 83516 x2

Components
Component Test Code* Component Chart Name LOINC
0092002 Pemphigoid Antibody Panel 48767-8
2010914 EER Pemphigoid Antibody Panel 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Bullous Pemphigoid
Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies, IgG and IgA, BP180 and BP230 Antibodies, IgG