• Assess and monitor disease in patient with pemphigoid or epidermolysis bullosa acquisita who has positive IgG basement membrane zone (BMZ) antibodies by indirect immunofluorescence, either epidermal (roof) pattern or dermal (floor) pattern, on split skin substrate.
• Consider ordering concurrently with Epithelial Basement Membrane Zone Antibody IgA (0092057), Bullous Pemphigoid Antigens (180 kDa and 230 kDa), IgG (0092566), and/or Collagen Type VII Antibody IgG by ELISA (2010905); alternatively order Basement Membrane Zone Antibody Panel (3001410) or Immunobullous Disease Panel, Epithelial (3001409).
• May use to screen for pemphigoid and other immunobullous diseases; however, this test will not detect IgA BMZ antibodies and has decreased sensitivity and specificity when compared with Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies, IgG and IgA, BP180 and BP230 Antibodies, IgG (0092001) and Basement Membrane Zone Antibody Panel (3001410), which includes epithelial basement membrane zone antibodies, IgG and IgA; BP180 and BP230 antibodies, IgG; and collagen type VII antibody, IgG.
(Indirect Fluorescent Antibody)
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Hemolyzed or lipemic specimens.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
No compliance statements are in use for this test.
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
|Component Test Code*||Component Chart Name||LOINC|
|0092056||Epithelial BMZ Ab, IgG|