Epithelial Basement Membrane Zone Antibody IgG

0092056
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Clinical Information for Immunodermatology (Serum Testing)

Ordering Recommendation

Use to assess and monitor positive IgG basement membrane zone antibodies, including epidermal (roof) pattern, dermal (floor) pattern, and combined on split skin substrate in patients with pemphigoid and epidermolysis bullosa acquisita (EBA), especially those with normal IgG BP 180, IgG BP 230, and IgG type VII collagen antibody levels.

Consider ordering concurrently with Epithelial Basement Membrane Zone Antibody IgA (0092057), Bullous Pemphigoid Antigens (180 kDa and 230 kDa), IgG (0092566), and/or Collagen Type VII Antibody IgG by ELISA (2010905); alternatively, order Basement Membrane Zone Antibody Panel (3001410) or Immunobullous Disease Panel, Epithelial (3001409), which includes this testing.

Decreased diagnostic sensitivity and specificity when testing for pemphigoid and EBA compared with Basement Membrane Zone Antibody Panel (3001410) or for pemphigoid compared with Pemphigoid Antibody Panel (0092001).

For initial pemphigoid or EBA diagnosis, Basement Membrane Zone Antibody Panel (3001410) or Immunobullous Disease Panel, Epithelial (3001409) is preferred.

Mnemonic

EBMZ IGG

Methodology

Semi-Quantitative Indirect Fluorescent Antibody (IFA)

Performed

Varies

Reported

4-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



Compliance Category

Not Applicable

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History

N/A

CPT Codes

88346; 88350

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Components

Component Test Code* Component Chart Name LOINC
0092056 Epithelial BMZ Ab, IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Epithelial Basement Membrane Zone Antibody IgG