Basement Membrane Zone (Epithelial) Antibodies, IgG by IIF

0092056
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Clinical Information for Immunodermatology (Serum Testing)

Ordering Recommendation

Use to assess and monitor IgG basement membrane zone antibodies in patients with pemphigoid, pemphigoid variants/subtypes, and epidermolysis bullosa acquisita (EBA), especially those with normal relevant IgG BP180, IgG BP230, and IgG type VII collagen antibody levels by ELISAs. Testing should be correlated with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572).

For initial pemphigoid or EBA diagnosis, a more comprehensive serum panel is preferred; refer to Immunobullous Disease Antibody Panel (3001409). Pemphigoid Antibody Panel (0092001) and Basement Membrane Zone Antibody Panel (3001410) have an increased diagnostic sensitivity and specificity for pemphigoid and pemphigoid/EBA, respectively.

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

Mnemonic

EBMZ IGG

Methodology

Semi-Quantitative Indirect Immunofluorescence (IIF)

Performed

Varies

Reported

4-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
11/14/2022
X
X
X
X
N/A

CPT Codes

88346; 88350

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Components

Component Test Code* Component Chart Name LOINC
0092056 Epithelial BMZ Ab, IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • atypical epithelial antibody-associated disease
  • basement membrane zone antibody-associated disease
  • bullous lupus erythematosus
  • bullous pemphigoid
  • cicatricial pemphigoid
  • epidermolysis bullosa acquisita
  • epithelial antibody-associated disease
  • Epithelial Basement Membrane Zone Antibody IgG
  • hemidesmosomal protein antibodies
  • hemidesmosome antibodies
  • IgG/IgA basement membrane zone antibodies
  • indirect fluorescence assay
  • indirect fluorescent antibody (IFA)
  • indirect immunofluorescent assay
  • linear IgG/IgA bullous dermatosis
  • mixed epithelial antibody-associated disease
  • mixed immunobullous disease of childhood
  • mucous membrane pemphigoid
  • ocular cicatricial pemphigoid
  • pemphigoid variants
  • salt-split skin test
  • subepithelial immunobullous disease
Basement Membrane Zone (Epithelial) Antibodies, IgG by IIF