0092056
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Basement Membrane Zone (Epithelial) Antibodies, IgG by IIF

EBMZ IGG
Example Reports
Enhanced Report
Negative
Positive

Ordering Recommendation

Use to assess and monitor IgG basement membrane zone antibodies in patients with pemphigoid, pemphigoid variants/subtypes, and epidermolysis bullosa acquisita (EBA), especially those with normal relevant IgG BP180, IgG BP230, and IgG type VII collagen antibody levels by ELISAs. Testing should be correlated with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572).

For initial pemphigoid or EBA diagnosis, a more comprehensive serum panel is preferred; refer to Immunobullous Disease Antibody Panel (3001409). Pemphigoid Antibody Panel (0092001) and Basement Membrane Zone Antibody Panel (3001410) have an increased diagnostic sensitivity and specificity for pemphigoid and pemphigoid/EBA, respectively.

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated: Ambient

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.

Remarks

As a general rule, serum specimens should be shipped to the laboratory as soon as possible.

Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.

Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Methodology

Semi-Quantitative Indirect Immunofluorescence (IIF)

Performed

Varies

Reported

3-9 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.

Hotline History

N/A

CPT Codes

88346; 88350

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Components

Component Test Code* Component Chart Name LOINC
0092056 Epithelial BMZ Ab, IgG
3004036 EER Epithelial BMZ Ab, IgG 45178-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • atypical epithelial antibody-associated disease
    basement membrane zone antibody-associated disease
    Brunsting-Perry cicatricial pemphigoid
    Brunsting-Perry pemphigoid
    bullous lupus erythematosus
    bullous pemphigoid
    cicatricial pemphigoid
    epidermolysis bullosa acquisita
    epithelial antibody-associated disease
    Epithelial Basement Membrane Zone Antibody IgG
    hemidesmosomal protein antibodies
    hemidesmosome antibodies
    IgG/IgA basement membrane zone antibodies
    indirect fluorescence assay
    indirect fluorescent antibody (IFA)
    indirect immunofluorescent assay
    linear IgA/IgG bullous dermatosis
    mixed epithelial antibody-associated disease
    mixed immunobullous disease of childhood
    mucous membrane pemphigoid
    ocular cicatricial pemphigoid
    pemphigoid variants
    salt-split skin test
    subepithelial immunobullous disease
Basement Membrane Zone (Epithelial) Antibodies, IgG by IIF