Use to assess and monitor IgA pemphigus or other nonclassical pemphigus subtypes with both IgA and IgG cell surface antibodies. Testing should be correlated with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572).
Consider ordering concurrently with serum Pemphigus Antibody Panel, IgG (0090650) if other types of pemphigus are diagnostic considerations, including intercellular IgG/IgA dermatosis. Alternatively, consider ordering the serum Immunobullous Disease Antibody Panel (3001409).
For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.
Semi-Quantitative Indirect Immunofluorescence (IIF)
Changed 05/09/05: 4-9 days
New York DOH Approval Status
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Hemolyzed or lipemic specimens. Plasma.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Refer to report
Performed by non-ARUP Laboratory
The methodology is indirect immunofluorescence (IIF) of serum on substrates with known epidermal (epithelial) cell surface desmosomal antigens (both intact human skin and monkey esophagus substrate). For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
|Component Test Code*||Component Chart Name||LOINC|
|0092106||Pemphigus Ab, IgA||42936-5|
- atypical epithelial antibody-associated disease
- desmosomal protein antibodies
- desmosome antibodies
- epithelial antibody-associated disease
- ICS antibodies
- IgA Pemphigus Antibodies
- indirect fluorescence assay
- indirect fluorescent antibody (IFA)
- indirect immunofluorescent assay
- intercellular IgG/IgA dermatosis
- intercellular substance antibodies
- intraepidermal neutrophilic IgA dermatosis
- mixed epithelial antibody-associated disease
- Pemphigus Antibody IgA
- subcorneal pustular dermatosis