Ordering Recommendation

Use to assess and monitor patients with possible IgA pemphigus, a rare disease with certain clinical and histopathologic subtypes. Testing should be clinically supported and/or correlated with concurrent Cutaneous Direct Immunofluorescence, Biopsy (0092572)
 
If other types of pemphigus are diagnostic considerations, order this test concurrently with Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650) or, for broader epithelial antibody testing, Immunobullous Disease Panel, Epithelial (3001409). Note that this test is included as part of the Immunobullous Disease Panel, Epithelial.

Mnemonic

IGA PEMPHI

Methodology

Semi-Quantitative Indirect Fluorescent Antibody (IFA)

Performed

Varies

Reported

3-7 days
Changed 05/09/05:  4-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



Compliance Category

Not Applicable

Note

The methodology is indirect immunofluorescence (IFA) of serum on substrates with known epidermal (epithelial) cell surface antigens (both intact human skin and monkey esophagus substrate). For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History

N/A

CPT Codes

88346; 88350

Components

Component Test Code* Component Chart Name LOINC
0092106 Pemphigus Ab, IgA 42936-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • IgA Pemphigus Antibodies
Pemphigus Antibody IgA (INACTIVE as of 11/15/21: Refer to 3004012 in the November Hotline)