Pemphigus Antibodies, IgA by IIF

0092106
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Clinical Information for Immunodermatology (Serum Testing)

Ordering Recommendation

Use to assess and monitor IgA pemphigus or other nonclassical pemphigus subtypes with both IgA and IgG cell surface antibodies. Testing should be correlated with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572).

Consider ordering concurrently with serum Pemphigus Antibody Panel, IgG (0090650) if other types of pemphigus are diagnostic considerations, including intercellular IgG/IgA dermatosis. Alternatively, consider ordering the serum Immunobullous Disease Antibody Panel (3001409).

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

Mnemonic

IGA PEMPHI

Methodology

Semi-Quantitative Indirect Immunofluorescence (IIF)

Performed

Varies

Reported

3-7 days
Changed 05/09/05:  4-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

The methodology is indirect immunofluorescence (IIF) of serum on substrates with known epidermal (epithelial) cell surface desmosomal antigens (both intact human skin and monkey esophagus substrate). For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History

N/A

CPT Codes

88346; 88350

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Components

Component Test Code* Component Chart Name LOINC
0092106 Pemphigus Ab, IgA 42936-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • atypical epithelial antibody-associated disease
  • desmosomal protein antibodies
  • desmosome antibodies
  • epithelial antibody-associated disease
  • ICS antibodies
  • IgA Pemphigus Antibodies
  • indirect fluorescence assay
  • indirect fluorescent antibody (IFA)
  • indirect immunofluorescent assay
  • intercellular IgG/IgA dermatosis
  • intercellular substance antibodies
  • intraepidermal neutrophilic IgA dermatosis
  • mixed epithelial antibody-associated disease
  • Pemphigus Antibody IgA
  • subcorneal pustular dermatosis
Pemphigus Antibodies, IgA by IIF