0092106
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Pemphigus Antibodies, IgA by IIF

IGA PEMPHI
Example Reports
Enhanced Report
Negative
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Clinical Information for Immunodermatology (Serum Testing)

Ordering Recommendation

Use to assess and monitor IgA pemphigus or other nonclassical pemphigus subtypes with both IgA and IgG cell surface antibodies. Testing should be correlated with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572).

Consider ordering concurrently with serum Pemphigus Antibody Panel, IgG (0090650) if other types of pemphigus are diagnostic considerations, including intercellular IgG/IgA dermatosis. Alternatively, consider ordering the serum Immunobullous Disease Antibody Panel (3001409).

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated/ambient

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.

Remarks

As a general rule, serum specimens should be shipped to the laboratory as soon as possible.

Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.

Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Methodology

Semi-Quantitative Indirect Immunofluorescence (IIF)

Performed

Varies

Reported

3-7 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

The methodology is indirect immunofluorescence (IIF) of serum on substrates with known epidermal (epithelial) cell surface desmosomal antigens (both intact human skin and monkey esophagus substrate). For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/21/2023
X
N/A

CPT Codes

88346; 88350

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Components

Component Test Code* Component Chart Name LOINC
0092106 Pemphigus Ab, IgA 42936-5
3004043 EER Pemphigus Ab, IgA 42936-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • epithelial antibody-associated disease
  • ICS antibodies
  • IgA Pemphigus Antibodies
  • indirect fluorescence assay
  • indirect fluorescent antibody (IFA)
  • indirect immunofluorescent assay
  • intraepidermal neutrophilic IgA dermatosis
  • mixed epithelial antibody-associated disease
  • subcorneal pustular dermatosis
  • desmosomal protein antibodies
  • desmosome antibodies
  • intercellular IgG/IgA dermatosis
  • atypical epithelial antibody-associated disease
  • intercellular substance antibodies
  • Pemphigus Antibody IgA
Pemphigus Antibodies, IgA by IIF