Islet Cell Cytoplasmic Antibody, IgG
Ordering Recommendation

May be useful with other markers (GAD, IA-2A, IAA and/or ZnT8A) to establish a diagnosis of autoimmune type 1 diabetes mellitus (type 1A diabetes mellitus) in patients who have been biochemically diagnosed with diabetes mellitus.

Semi-Quantitative Indirect Fluorescent Antibody
Mon, Wed, Fri
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Plasma. Contaminated, hemolyzed, or severely lipemic specimens.  
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
< 1:4 No antibody detected.
Interpretive Data
Islet cell antibodies (ICAs) are associated with type 1 diabetes (T1D), an autoimmune endocrine disorder. ICAs may be present years before the onset of clinical symptoms. To calculate Juvenile Diabetes Foundation (JDF) units: multiply the titer x 5 (1:8 8 x 5=40 JDF Units).

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0050138Islet Cell Cytoplasmic Antibody, IgG13927-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Anti-Islet Cell Antibody
  • beta cell
  • Cytoplasmic Islet Cell Ab
  • ICA
  • Islet Cell Ab IgG