Islet Cell Cytoplasmic Antibody, IgG
0050138
Ordering Recommendation
Not recommended in routine evaluation or management of diabetes mellitus (DM). Glutamic Acid Decarboxylase Antibody (GAD) (2001771) and IA-2 Antibody (insulinoma antigen 2) (0050202) recommended for initial screening of suspected cases of type 1 DM.
Mnemonic
ANTI-ISLET
Methodology
Semi-Quantitative Indirect Fluorescent Antibody
Performed
Mon, Wed, Fri
Reported
1-3 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma. Contaminated, hemolyzed, or severely lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
< 1:4 No antibody detected.  
Interpretive Data
Islet cell antibodies (ICAs) are associated with type 1 diabetes (T1D), an autoimmune endocrine disorder. These antibodies may be present in individuals years before the onset of clinical symptoms. To calculate Juvenile Diabetes Foundation (JDF) units: multiply the titer x 5 (1:8 8 x 5=40 JDF Units).  
Note
 
CPT Code(s)
86341
Components
Component Test Code*Component Chart Name
0050138Islet Cell Cytoplasmic Antibody, IgG
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Aliases
  • ?-cells
  • Anti-Islet Cell Antibody
  • beta cell
  • Cytoplasmic Islet Cell Ab
  • ICA
  • Islet Cell Ab IgG