Islet Cell Cytoplasmic Antibody, IgG
0050138
Ordering Recommendation
Not recommended in routine evaluation or management of diabetes mellitus (DM). Glutamic Acid Decarboxylase Antibody (GAD) (2001771) and IA-2 Antibody (insulinoma antigen 2) (0050202) recommended for initial screening of suspected cases of type 1 DM.
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Mnemonic
ANTI-ISLET
Methodology
Semi-Quantitative Indirect Fluorescent Antibody
Performed
Mon, Wed, Fri
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma. Contaminated, hemolyzed, or severely lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
< 1:4 No antibody detected.
Interpretive Data
Islet cell antibodies (ICAs) are associated with type 1 diabetes (T1D), an autoimmune endocrine disorder. These antibodies may be present in individuals years before the onset of clinical symptoms. To calculate Juvenile Diabetes Foundation (JDF) units: multiply the titer x 5 (1:8 8 x 5 = 40 JDF Units).
Note
CPT Code(s)
86341
Components
Component Test Code*Component Chart Name
0050138Islet Cell Cytoplasmic Antibody, IgG
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Cross References
  • ?-cells
  • Anti-Islet Cell Antibody
  • beta cell
  • Cytoplasmic Islet Cell Ab
  • ICA
  • Islet Cell Ab IgG