Islet Cell Cytoplasmic Antibody, IgG
Ordering Recommendation
Not recommended in routine evaluation or management of diabetes mellitus (DM). Glutamic Acid Decarboxylase Antibody (GAD) (2001771) and IA-2 Antibody (insulinoma antigen 2) (0050202) recommended for initial screening of suspected cases of type 1 DM.
Semi-Quantitative Indirect Fluorescent Antibody
Mon, Wed, Fri
1-3 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Plasma. Contaminated, hemolyzed, or severely lipemic specimens.  
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
< 1:4 No antibody detected.  
Interpretive Data
Islet cell antibodies (ICAs) are associated with type 1 diabetes (T1D), an autoimmune endocrine disorder. ICAs may be present years before the onset of clinical symptoms. To calculate Juvenile Diabetes Foundation (JDF) units: multiply the titer x 5 (1:8 8 x 5=40 JDF Units).

Compliance Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0050138Islet Cell Cytoplasmic Antibody, IgG13927-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Anti-Islet Cell Antibody
  • beta cell
  • Cytoplasmic Islet Cell Ab
  • ICA
  • Islet Cell Ab IgG