Islet Antigen-2 (IA-2) Autoantibody, Serum
Ordering Recommendation

If pursuing antibody testing to determine autoimmune diabetes mellitus, perform at least two antibody tests. In most cases, use glutamic acid decarboxylase antibody in combination with another antibody test. Other antibody tests include Glutamic Acid Decarboxylase Antibody (2001771), Insulin Antibody (0099228), Islet Cell Cytoplasmic Antibody, IgG (0050138), and Zinc Transporter 8 Antibody (2006196). Most useful to establish autoimmune etiology in previously diagnosed type 1 DM. Do not use to differentiate type 1 DM from type 2 DM, for most cases.

Quantitative Enzyme-Linked Immunosorbent Assay
Mon, Wed, Fri
2-10 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Plain Red or Serum Separator Tube (SST). 
Specimen Preparation
Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.35 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Plasma. Specimens submitted in frozen Serum Separator Tubes (SST). Grossly hemolyzed, icteric, or lipemic specimens. 
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month 
Reference Interval
0.0-7.4 Units/mL
Interpretive Data
A value greater than or equal to 7.5 Units/mL is considered positive for IA-2 autoantibody.

This assay is intended for the quantitative determination of autoantibodies to Islet Antigen-2 (IA-2) in human serum. Results should be interpreted within the context of clinical symptoms.

Hotline History
View Hotline History
Component Test Code*Component Chart NameLOINC
3001500IA-2, Autoantibody56718-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Anti-IA2 Antibody
  • IA-2
  • IA-2 AB
  • IA-2 Autoantibody
  • ICA-512
  • Islet Antigen 2
  • Islet Cell Antibody
  • Islet Cell Antigen (ICA) 512
  • Tyrosine Phosphatase-Like Protein Antibodies
  • tyrosine phosphatase-related islet antigen 2