Ordering Recommendation

Use to assess and monitor patients with positive IgG cell surface antibodies in pemphigus, especially in patients with normal IgG desmoglein 1 and IgG desmoglein 3 antibody levels.

Decreased diagnostic sensitivity and specificity when testing for pemphigus compared to Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650).
 
For initial pemphigus diagnostic testing, the preferred test is Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650) or Immunobullous Disease Panel, Epithelial (3001409).   

Mnemonic
IGG EPI AB
Methodology

Semi-Quantitative Indirect Fluorescent Antibody (IFA)

Performed

Varies

Reported

4-9 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



Compliance Category

Not Applicable

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History
N/A
CPT Codes

88346; 88350

Components
Component Test Code* Component Chart Name LOINC
0090268 Epithelial Cell Surface Ab IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Epithelial Cell Surface Antibody IgG