Ordering Recommendation
Use to assess and monitor cell surface antibodies in patients with IgG pemphigus variants with normal IgG desmoglein 1 and IgG desmoglein 3 antibody levels. Testing should be correlated initially with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572). Serum Pemphigus Antibody Panel, IgG (0090650) has increased diagnostic sensitivity and specificity when testing for pemphigus. For comprehensive testing, consider ordering the Immunobullous Disease Antibody Panel (3001409).
For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.
Mnemonic
Methodology
Semi-Quantitative Indirect Immunofluorescence (IIF)
Performed
Varies
Reported
4-9 days
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Hemolyzed or lipemic specimens. Plasma.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Reference Interval
By report
Interpretive Data
Refer to report
Performed by non-ARUP Laboratory
Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
Hotline History
Hotline History
CPT Codes
88346; 88350
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0090268 | Epithelial Cell Surface Ab IgG |
Aliases
- atypical epithelial antibody-associated disease
- desmosomal protein antibodies
- desmosome antibodies
- endemic pemphigus
- epithelial antibody-associated disease
- Epithelial Cell Surface Antibody IgG
- fogo selvagem
- ICS antibodies
- indirect fluorescence assay
- indirect fluorescent antibody (IFA)
- indirect immunofluorescent assay
- intercellular IgG/IgA dermatosis
- intercellular substance antibodies
- mixed epithelial antibody-associated disease
- pemphigus erythematosus
- pemphigus foliaceus
- pemphigus vegetans
- pemphigus vulgaris