Cell Surface (Epithelial) Antibodies, IgG by IIF

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Clinical Information for Immunodermatology (Serum Testing)

Ordering Recommendation

Use to assess and monitor cell surface antibodies in patients with IgG pemphigus variants with normal IgG desmoglein 1 and IgG desmoglein 3 antibody levels. Testing should be correlated initially with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572). Serum Pemphigus Antibody Panel, IgG (0090650) has increased diagnostic sensitivity and specificity when testing for pemphigus. For comprehensive testing, consider ordering the Immunobullous Disease Antibody Panel (3001409).

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

Mnemonic

IGG EPI AB

Methodology

Semi-Quantitative Indirect Immunofluorescence (IIF)

Performed

Varies

Reported

4-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History

N/A

CPT Codes

88346; 88350

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Components

Component Test Code* Component Chart Name LOINC
0090268 Epithelial Cell Surface Ab IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • atypical epithelial antibody-associated disease
  • desmosomal protein antibodies
  • desmosome antibodies
  • endemic pemphigus
  • epithelial antibody-associated disease
  • Epithelial Cell Surface Antibody IgG
  • fogo selvagem
  • ICS antibodies
  • indirect fluorescence assay
  • indirect fluorescent antibody (IFA)
  • indirect immunofluorescent assay
  • intercellular IgG/IgA dermatosis
  • intercellular substance antibodies
  • mixed epithelial antibody-associated disease
  • pemphigus erythematosus
  • pemphigus foliaceus
  • pemphigus vegetans
  • pemphigus vulgaris
Cell Surface (Epithelial) Antibodies, IgG by IIF