Cell Surface (Epithelial) Antibodies, IgG by IIF
Ordering Recommendation
Use to assess and monitor cell surface (CS) antibodies, also known as intercellular substance (ICS) antibodies, in patients with IgG pemphigus variants with normal IgG desmoglein 1 and IgG desmoglein 3 antibody levels. Testing should be correlated initially with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572). Serum Pemphigus Antibody Panel, IgG (0090650) has increased diagnostic sensitivity and specificity when testing for pemphigus. For comprehensive testing, consider ordering the Immunobullous Disease Antibody Panel (3001409).
For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)
Refrigerated/ambient
Hemolyzed or lipemic specimens. Plasma.
As a general rule, serum specimens should be shipped to the laboratory as soon as possible.
Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Methodology
Semi-Quantitative Indirect Immunofluorescence (IIF)
Performed
Varies
Reported
3-9 days
Reference Interval
By report
Interpretive Data
Refer to report
Performed by non-ARUP Laboratory
Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at <!--StartFragment -->801-581-7139.<!--EndFragment -->
Hotline History
Hotline History
CPT Codes
88346; 88350
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0090268 | Epithelial Cell Surface Ab IgG | |
3004037 | EER Epithelial Cell Surface Antibody IgG |
Aliases
- atypical epithelial antibody-associated disease
desmosomal protein antibodies
desmosome antibodies
endemic pemphigus
epithelial antibody-associated disease
Epithelial Cell Surface Antibody IgG
fogo selvagem
ICS antibodies
IgG pemphigus variant
IgG variant pemphigus
indirect fluorescence assay
indirect fluorescent antibody (IFA)
indirect immunofluorescent assay
intercellular IgG/IgA dermatosis
intercellular substance (ICS) antibodies
mixed epithelial antibody-associated disease
pemphigus erythematosus
pemphigus foliaceus
pemphigus vegetans
pemphigus vulgaris
prickle cell antibodies
Senear-Usher
Test previously known as Epithelial Cell Surface Antibody IgG