Monitor patient with pemphigus who has positive IgG cell surface antibodies, but normal IgG desmoglein 1 and/or 3 antibody levels. For initial diagnosis and disease monitoring, the preferred test is Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650); panel components include IgG epithelial cell surface antibodies and IgG desmoglein 1 and 3.
May use to screen for pemphigus or pemphigoid; however, this test has decreased sensitivity and specificity when compared to Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650) or Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies, IgG and IgA, BP180 and BP230 Antibodies, IgG (0092001).
Indirect Fluorescent Antibody
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Hemolyzed or lipemic specimens.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
No compliance statements are in use for this test.
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
|Component Test Code*||Component Chart Name||LOINC|
|0090268||Epithelial Cell Surface Ab IgG|