Ordering Recommendation

Use to assess and monitor cell surface (CS) antibodies, also known as intercellular substance (ICS) antibodies, in patients with IgG pemphigus variants with normal IgG desmoglein 1 and IgG desmoglein 3 antibody levels. Testing should be correlated initially with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572). Serum Pemphigus Antibody Panel, IgG (0090650) has increased diagnostic sensitivity and specificity when testing for pemphigus. For comprehensive testing, consider ordering the Immunobullous Disease Antibody Panel (3001409).

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.


As a general rule, serum specimens should be shipped to the laboratory as soon as possible.

Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.


Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely


Semi-Quantitative Indirect Immunofluorescence (IIF)




3-9 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory


For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.

Hotline History


CPT Codes

88346; 88350


Component Test Code* Component Chart Name LOINC
0090268 Epithelial Cell Surface Ab IgG
3004037 EER Epithelial Cell Surface Antibody IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • atypical epithelial antibody-associated disease
  • desmosomal protein antibodies
  • desmosome antibodies
  • endemic pemphigus
  • epithelial antibody-associated disease
  • Epithelial Cell Surface Antibody IgG
  • fogo selvagem
  • ICS antibodies
  • IgG pemphigus variant
  • IgG variant pemphigus
  • indirect fluorescence assay
  • indirect fluorescent antibody (IFA)
  • indirect immunofluorescent assay
  • intercellular IgG/IgA dermatosis
  • intercellular substance (ICS) antibodies
  • mixed epithelial antibody-associated disease
  • pemphigus erythematosus
  • pemphigus foliaceus
  • pemphigus vegetans
  • pemphigus vulgaris
  • prickle cell antibodies
  • Senear-Usher
  • Test previously known as Epithelial Cell Surface Antibody IgG
Cell Surface (Epithelial) Antibodies, IgG by IIF