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Desmoglein 1 and Desmoglein 3 Antibodies in Pemphigus, IgG
0090649
Ordering Recommendation

• Monitor disease in patient previously diagnosed with pemphigus and increased IgG desmoglein 1 and/or 3 antibodies; antibody levels correlate with disease activity. Consider ordering with IgG epithelial cell surface antibody (0090266).
• If used to screen for pemphigus, this test has decreased sensitivity and specificity when compared to the pemphigus antibody panel (0090650).
• For initial diagnosis and monitoring disease, the antibody panel testing for pemphigus (0090650) is preferred; panel components include IgG antibody testing for epithelial cell surface and IgG desmoglein 1 and 3.
• For diagnosing rare types of pemphigus, refer to IgA pemphigus antibody (0092106) and paraneoplastic pemphigus (0092107).

Mnemonic
IGG DESMOG
Methodology
Enzyme-Linked Immunosorbent Assay
Performed
Varies
Reported
4-9 days
New York DOH Approval Status
This test is New York DOH approved.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Plain red or serum separator tube.  
Specimen Preparation
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Hemolyzed or lipemic specimens.  
Remarks
 
Stability
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely  
Reference Interval
By report
Interpretive Data


Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
CPT Code(s)
83516 x2
Components
Component Test Code*Component Chart NameLOINC
0090653Desmoglein 1 and 3 Antibodies, IgG
2010912EER Desmoglein 1 and 3 Antibodies, IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases

Performed at UUHC-Immunodermatology