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Desmoglein 1 and Desmoglein 3 Antibodies in Pemphigus, IgG
0090649
Ordering Recommendation
Monitor disease in patient previously diagnosed with pemphigus and increased IgG desmoglein 1 and/or 3 antibodies; antibody levels correlate with disease activity. Consider ordering with IgG epithelial cell surface antibody (0090266).
If used to screen for pemphigus, this test has decreased sensitivity and specificity when compared to the pemphigus antibody panel (0090650).
For initial diagnosis and monitoring disease, the antibody panel testing for pemphigus (0090650) is preferred; panel components include IgG antibody testing for epithelial cell surface and IgG desmoglein 1 and 3.
For diagnosing rare types of pemphigus, refer to IgA pemphigus antibody (0092106) and paraneoplastic pemphigus (0092107).
Mnemonic
IGG DESMOG
Methodology
Enzyme-Linked Immunosorbent Assay
Performed
Varies
Reported
4-9 days
New York DOH Approval Status
This test is New York DOH approved.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Plain red or serum separator tube.  
Specimen Preparation
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Hemolyzed or lipemic specimens.  
Remarks
 
Stability
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely  
Reference Interval
By report
Interpretive Data


Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
CPT Code(s)
83516 x2
Components
Component Test Code*Component Chart NameLOINC
0090653Desmoglein 1 and 3 Antibodies, IgG
2010912EER Desmoglein 1 and 3 Antibodies, IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases

Performed at UUHC-Immunodermatology