0090266
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Cell Surface (Epithelial) Antibodies, IgG by IIF

IGG EPI AB
Example Reports
Negative
Positive

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Clinical Information for Immunodermatology (Serum Testing)

Ordering Recommendation

Use to assess and monitor cell surface (CS) antibodies, also known as intercellular substance (ICS) antibodies, in patients with IgG pemphigus variants with normal IgG desmoglein 1 and IgG desmoglein 3 antibody levels. Testing should be correlated initially with concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572). Serum Pemphigus Antibody Panel, IgG (0090650) has increased diagnostic sensitivity and specificity when testing for pemphigus. For comprehensive testing, consider ordering the Immunobullous Disease Antibody Panel (3001409).

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated/ambient

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.

Remarks

As a general rule, serum specimens should be shipped to the laboratory as soon as possible.

Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.

Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Methodology

Semi-Quantitative Indirect Immunofluorescence (IIF)

Performed

Varies

Reported

3-9 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/21/2023
X
11/14/2022
X
X
X
X
N/A

CPT Codes

88346; 88350

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Components

Component Test Code* Component Chart Name LOINC
0090268 Epithelial Cell Surface Ab IgG
3004037 EER Epithelial Cell Surface Antibody IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • atypical epithelial antibody-associated disease
  • desmosomal protein antibodies
  • desmosome antibodies
  • endemic pemphigus
  • epithelial antibody-associated disease
  • Epithelial Cell Surface Antibody IgG
  • fogo selvagem
  • ICS antibodies
  • IgG pemphigus variant
  • IgG variant pemphigus
  • indirect fluorescence assay
  • indirect fluorescent antibody (IFA)
  • indirect immunofluorescent assay
  • intercellular IgG/IgA dermatosis
  • intercellular substance (ICS) antibodies
  • mixed epithelial antibody-associated disease
  • pemphigus erythematosus
  • pemphigus foliaceus
  • pemphigus vegetans
  • pemphigus vulgaris
  • prickle cell antibodies
  • Senear-Usher
  • Test previously known as Epithelial Cell Surface Antibody IgG
Cell Surface (Epithelial) Antibodies, IgG by IIF