Ordering Recommendation

Not recommended for the diagnosis of fungal infection. Refer to individual fungus-specific testing according to patient exposure: Coccidioides Antibodies Panel, Serum (0050588); Aspergillus Antibodies by Immunodiffusion, Serum (0050171); Histoplasma Antibodies by Complement Fixation and Immunodiffusion, Serum (0050627); and Blastomyces dermatitidis Antibodies by Immunoassay (3000236).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

  Serum separator tube (SST) or plain red

Specimen Preparation

  Separate from cells ASAP or within 2 hours of collection. Transfer 2.5 mL serum to an ARUP standard transport tube. (Min: 1.5 mL) Parallel testing is preferred and convalescent specimens mustbe received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent."

Storage/Transport Temperature

  Preferred transport temp: Refrigerated. Also acceptable: Frozen.

Unacceptable Conditions

  Contaminated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

  After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Methodology

  Semi-Quantitative Complement Fixation / Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA) / Qualitative Immunodiffusion

Performed

    Sun-Sat

Reported

    2-8 days

Reference Interval

  Refer to report

Test Number
Components
Reference Interval
  Blastomyces Antibodies EIA, SER 0.9 IV or less
  Histoplasma Yeast Antibodies by CF Less than 1:8
  Histoplasma Mycelia Antibodies by CF Less than 1:8
  Coccidioides by Immunodiffusion, Serum Not detected.
  Histoplasma Antibodies by ID Not detected.
  Blastomyces Antibodies by ID Not detected.
  Aspergillus Antibodies by ID Not detected
  Coccidioides Antibody by CF Less than 1:2

Interpretive Data



Compliance Category

FDA

Note

  This test detects antibodies to Coccidioides and Histoplasma by complement fixation, Blastomyces by immunoassay, and Coccidioides , Blastomyces , Histoplasma, and Aspergillus by immunodiffusion.

Hotline History

N/A

CPT Codes

  86635 x2, 86698 x3, 86606, 86612 x2

Components

Component Test Code* Component Chart Name LOINC
0050170 Coccidioides Antibody by CF 33380-7
0050171 Aspergillus Antibodies by ID 5052-6
0050172 Blastomyces Antibodies by ID 5058-3
0050174 Histoplasma Antibodies by ID 5218-3
0050183 Coccidioides by Immunodiffusion, Serum 5095-5
0050330 Histoplasma Mycelia Antibodies by CF 20573-2
0050335 Histoplasma Yeast Antibodies by CF 20574-0
3000237 Blastomyces Antibodies EIA, SER 16471-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Aspergillus
  • Blastomyces
  • Coccidiodes
  • Histoplasma
  • Coccidioidomycosis
  • Valley Fever
  • Histoplasma capsulatum
  • Histoplasmosis
  • Precipitin
  • Blastomycosis
  • TP
  • H antigen
  • Histoplasma capsulatum
  • Histoplasmosis
  • M antigen
  • Aspergillosis
Fungal Antibodies Extended Panel, Serum (Test Delay as of 06/02/2026)