Preferred test for establishment of diagnosis is Coccidioides Antibodies Reflexive Panel (3001982).
Semi-Quantitative Complement Fixation/Qualitative Immunodiffusion/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer two 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.
Other body fluids. Hemolyzed, icteric, or lipemic specimens.
Mark specimens plainly as "acute" or "convalescent."
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Effective November 18, 2013
|0050170||Coccidioides Antibody by CF||Less than 1:2|
|0050183||Coccidioides immitis Antibodies by Immunodiffusion (INACTIVE as of 11/16/20: Refer to 3001982 in the November Hotline)||None detected.|
|0050179||Coccidioides Antibody, IgG by ELISA||
|0050178||Coccidioides Antibody, IgM by ELISA||
Refer to report.
For Coccidioides, immunodiffusion (ID) measures IgM antibody, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired specimens are preferred. Acute and convalescent specimens (drawn at least 21 days apart), showing a fourfold or greater rise in titer, are diagnostic.
Negative fungal serology does not rule out the possibility of current infection.
|Component Test Code*||Component Chart Name||LOINC|
|0050170||Coccidioides Antibody by CF||33380-7|
|0050178||Coccidioides Antibody, IgM by ELISA||90448-2|
|0050179||Coccidioides Antibody, IgG by ELISA||27009-0|
|0050183||Coccidioides immitis Abs, Precipitin||5095-5|
- Cocci Antibodies Panel
- COCCI CF,ID,ELISA
- Coccidioides Antibodies Serum panel
- San Joaquin Fever Antibodies
- Valley Fever Antibodies