Ordering Recommendation

Preferred test for establishment of diagnosis is Coccidioides Antibodies Reflexive Panel (3001982).

Mnemonic
COCCI PAN
Methodology

Semi-Quantitative Complement Fixation/Qualitative Immunodiffusion/Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun-Sat

Reported

2-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer two 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Other body fluids. Hemolyzed, icteric, or lipemic specimens.

Remarks

Mark specimens plainly as "acute" or "convalescent."

Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Effective November 18, 2013

Test Number
Components
Reference Interval
0050170 Coccidioides Antibody by CF Less than 1:2
0050183 Coccidioides immitis Antibodies by Immunodiffusion None detected.
0050179 Coccidioides Antibody, IgG by ELISA
0.9 IV or less Negative - No significant level of Coccidioides IgG antibody detected.
1.0-1.4 IV Equivocal - Questionable presence of Coccidioides IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.

0050178 Coccidioides Antibody, IgM by ELISA
0.9 IV or less Negative - No significant level of Coccidioides IgM antibody detected.
1.0-1.4 IV Equivocal - Questionable presence of Coccidioides IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Interpretive Data

Refer to report.

No compliance statements are in use for this test.

Note

For Coccidioides, immunodiffusion (ID) measures IgM antibody, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired specimens are preferred. Acute and convalescent specimens (drawn at least 21 days apart), showing a fourfold or greater rise in titer, are diagnostic.

Negative fungal serology does not rule out the possibility of current infection.

Hotline History
N/A
CPT Codes

86635 x4

Components
Component Test Code* Component Chart Name LOINC
0050170 Coccidioides Antibody by CF 33380-7
0050178 Coccidioides Antibody, IgM by ELISA 90448-2
0050179 Coccidioides Antibody, IgG by ELISA 27009-0
0050183 Coccidioides immitis Abs, Precipitin 5095-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cocci Antibodies Panel
  • COCCI CF,ID,ELISA
  • Coccidioides Antibodies Serum panel
  • San Joaquin Fever Antibodies
  • Valley Fever Antibodies
Coccidioides Antibodies Panel, Serum by CF, ID, ELISA