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Red Blood Cell Antigen Genotyping, Fetal
Ordering Recommendation
Fetal genotyping for 35 red blood cell antigens and phenotypic variants to assess risk for alloimmune hemolytic disease. For parental or neonatal testing, refer to Red Blood Cell Antigen Genotyping (3001053). This test does not assess for RhD; to test for RhD, refer to RhD Gene (RHD) Copy Number, Fetal (3016640).
New York DOH Approval Status
Specimen Required
Amniotic fluid
OR cultured amniocytes OR cultured CVS: Two T-25 flasks at 80 percent confluency.
AND maternal whole blood: lavender (K2 or K3EDTA), pink (K2EDTA), or yellow (ACD solution A or B).
If the client is unable to culture, order test Cytogenetics Grow and Send (ARUP test code 0040182) in addition to this test and ARUP will culture upon receipt (culturing fees will apply). If you have any questions, contact ARUP's Genetics Processing at 800-522-2787 ext. 3301.
Amniotic fluid: Transport 10 mL amniotic fluid in a sterile container. (Min: 5 mL)
OR cultured amniocytes OR cultured CVS: Fill flasks with culture media. Backup cultures must be retained at the client's institution until testing is complete.
AND Maternal whole blood: Transport 2 mL whole blood (min: 1 mL).
Amniotic fluid, cultured amniocytes or cultured CVS: CRITICAL TEMPERATURE. Must be received within 48 hours of shipment due to lability of cells.
Maternal whole blood: room temperature.
Frozen specimens in glass collection tubes.
The Patient History Form is available on the ARUP website or by contacting ARUP Client Services.
Fetal specimens: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
Maternal whole blood: Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
Methodology
Polymerase Chain Reaction (PCR)/Fluorescence Monitoring/Fragment Analysis
Performed
Varies
Reported
3-10 days
If culture is required, an additional 1 to 2 weeks is required for processing time.
Reference Interval
Interpretive Data
Refer to report
Laboratory Developed Test (LDT)
Note
Hotline History
Hotline History
CPT Codes
0001U; 81265 Fetal Cell Contamination (FCC)
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050548 | Maternal Contamination Study Fetal Spec | 59266-7 |
| 0050612 | Maternal Contam Study, Maternal Spec | 66746-9 |
| 3001055 | Rh Antigen C/c | |
| 3001056 | Rh Antigen E/e | |
| 3001057 | Rh Antigen V/VS | |
| 3001058 | Kell Antigen K/k | |
| 3001059 | Kell Antigen Kpa/Kpb | |
| 3001060 | Kell Antigen Jsa/Jsb | |
| 3001061 | Duffy Antigen Fya/Fyb | |
| 3001062 | Kidd Antigen Jka/Jkb | |
| 3001063 | MNS Antigen MN | |
| 3001064 | MNS Antigen S/s/U | |
| 3001065 | Lutheran Antigen Lua/Lub | |
| 3001066 | Dombrock Antigen Doa/Dob | |
| 3001067 | Dombrock Antigen Hy | |
| 3001068 | Dombrock Antigen Joa | |
| 3001069 | Landsteiner-Wiener Antigen LWa/LWb | |
| 3001070 | Diego Antigen Dia/Dib | |
| 3001071 | Colton Antigen Coa/Cob | |
| 3001072 | Scianna Antigen Sc1/Sc2 | |
| 3001073 | Hemoglobin S Antigen | |
| 3016643 | RBC Antigen Genotyping, Fetal Specimen | 31208-2 |
| 3016644 | RBC Antigen Genotyping Fetal, Interp | 50398-7 |
Aliases
- Colton genotyping (Coa, Cob)
- Diego genotyping (Dia, Dib)
- Dombrock genotyping (Doa, Dob, Hy, Joa)
- Duffy genotyping (Fya, Fyb, Fyb-67C)
- Kell genotyping (K, k, Kpa, Kpb, Jsa, Jsb)
- Kidd genotyping (Jka, Jkb)
- Landsteiner-Wiener genotyping (LWa, LWb)
- Lutheran genotyping (Lua, Lub)
- MNS genotyping (M, N, S, s, U, Uvar, Uneg)
- Rh genotyping (C, c, E, e, V, VS)
- Scianna genotyping (Sc1, Sc2)
