Ordering Recommendation

Use to assess and monitor disease in patients with possible dermatitis herpetiformis. Testing should be clinically supported and/or correlated with concurrent Cutaneous Direct Immunofluorescence, Biopsy (0092572).

IgA epidermal transglutaminase (transglutaminase 3 or TG3) antibodies are pathogenic in dermatitis herpetiformis, and an increased level is distinctly characteristic of the disorder; of note, most patients with dermatitis herpetiformis have associated celiac disease; therefore, testing should be performed in conjunction with serological testing for celiac disease.

For initial diagnosis and assessment of disease progression/changes and to distinguish from other immunobullous diseases with epithelial antibodies, order with Celiac Disease Reflexive Cascade (2008114) and Immunobullous Disease Panel, Epithelial (3001409), or with Celiac Disease Reflexive Cascade (2008114) and Basement Membrane Zone Antibody Panel (3001410) and Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650).

Mnemonic
EPI TRANS
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Varies

Reported

28-31 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data



No compliance statements are in use for this test.

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History
N/A
CPT Codes

83516

Components
Component Test Code* Component Chart Name LOINC
2010903 Epidermal Transglutaminase Ab IgA, ELISA
2010904 EER Epidermal Transglutaminase Ab, IgA
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Epidermal Transglutaminase (etG/tTG3) Antibody, IgA by ELISA