Use to assess and monitor disease in patients with possible dermatitis herpetiformis. Testing should be clinically supported and/or correlated with concurrent Cutaneous Direct Immunofluorescence, Biopsy (0092572).
IgA epidermal transglutaminase (transglutaminase 3 or TG3) antibodies are pathogenic in dermatitis herpetiformis, and an increased level is distinctly characteristic of the disorder; of note, most patients with dermatitis herpetiformis have associated celiac disease; therefore, testing should be performed in conjunction with serological testing for celiac disease.
For initial diagnosis and assessment of disease progression/changes and to distinguish from other immunobullous diseases with epithelial antibodies, order with Celiac Disease Reflexive Cascade (2008114) and Immunobullous Disease Panel, Epithelial (3001409), or with Celiac Disease Reflexive Cascade (2008114) and Basement Membrane Zone Antibody Panel (3001410) and Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650).
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
New York DOH Approval Status
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Hemolyzed or lipemic specimens.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Performed by non-ARUP Laboratory
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
|Component Test Code*||Component Chart Name||LOINC|
|2010903||Epidermal Transglutaminase Ab IgA, ELISA|
|2010904||EER Epidermal Transglutaminase Ab, IgA||11502-2|