Ordering Recommendation

Effective test for secondary confirmation of hemoglobin (Hb) S. Not recommended for newborns <6 months due to high concentration of HbF. Confirm results with Hemoglobin Evaluation with Reflex to Electrophoresis and/or RBC Solubility (0050610). 

Mnemonic
SICKLE
Methodology

RBC Solubility

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Transport 5 mL whole blood. (Min: 0.2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval
Interpretive Data

Refer to report.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
Components
Component Test Code* Component Chart Name LOINC
2013400 Sickle Cell Solubility Result 6864-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Hb S
  • Hgb S
  • Sickle Cell Anemia Screen
  • Sickle Cell Disease
Hemoglobin S, Sickle Solubility