Ordering Recommendation

Effective test for secondary confirmation of hemoglobin (Hb) S. Not recommended for newborns <6 months due to high concentration of HbF. Confirm results with Hemoglobin Evaluation with Reflex to Electrophoresis and/or RBC Solubility (0050610). 

Mnemonic

SICKLE

Methodology

RBC Solubility

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Transport 5 mL whole blood. (Min: 0.2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

Interpretive Data

Refer to report.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

85660

Components

Component Test Code* Component Chart Name LOINC
2013400 Sickle Cell Solubility Result 6864-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Hb S
  • Hgb S
  • Sickle Cell Anemia Screen
  • Sickle Cell Disease
Hemoglobin S, Sickle Solubility