Ordering Recommendation

Use to diagnose patients for mucopolysaccharidosis type I (also known as MPS I, Hurler, Scheie, and Hurler-Scheie syndromes). To screen for all types of MPS, refer to Mucopolysaccharides Screen - Electrophoresis and Quantitation, Urine (0081352). To monitor glycosaminoglycans (GAGs) in patients previously diagnosed with MPS, refer to Mucopolysaccharides, Quantitative, Urine (0081357).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Yellow (ACD Solution B), lavender (K2EDTA), or lavender (K3EDTA).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Room temperature (preferred) or refrigerated

Unacceptable Conditions

Grossly hemolyzed or heparinized specimens.

Remarks

Additional information is required: Clinical Indication for testing.

Stability

Ambient: 3 days; Refrigerated: 3 days; Frozen: Unacceptable

Methodology

Quantitative Fluorometry

Performed

Mon

Reported

3-10 days

Reference Interval

12-65 nmol hydrolyzed/hr/mg protein

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

82657

Components

Component Test Code* Component Chart Name LOINC
2011416 Alpha-Iduronidase Activity, Leukocytes 24057-2
2011417 Alpha-Iduronidase, Leukocytes, Interp 48767-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Hunter
  • Hunter-Scheie
  • Mucopolysaccharidosis Type I
  • Scheie
Alpha-Iduronidase Enzyme Activity in Leukocytes