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Alpha-Iduronidase Enzyme Activity in Leukocytes
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Ordering Recommendation
Use to diagnose patients for mucopolysaccharidosis type I (also known as MPS I, Hurler, Scheie, and Hurler-Scheie syndromes). To screen for all types of MPS, refer to Mucopolysaccharides Screen - Electrophoresis & Quantitation, Urine (0081352). To monitor glycosaminoglycans (GAGs) in patients previously diagnosed with MPS, refer to Mucopolysaccharides, Quantitative, Urine (0081357).
Mnemonic
Methodology
Quantitative Fluorometry
Performed
Varies
Reported
3-10 days
New York DOH Approval Status
Specimen Required
Yellow (ACD Solution B), Lavender (K2EDTA), or Lavender (K3EDTA).
Transport 3 mL whole blood. (Min: 1 mL)
Room Temperature (Preferred) or Refrigerated
Grossly hemolyzed or heparinized specimens.
Additional information is required: Clinical Indication for testing.
Ambient: 3 days; Refrigerated: 3 days; Frozen: Unacceptable
Reference Interval
12 - 65 nmol hydrolyzed/hr/mg protein
Interpretive Data
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
82657
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2011416 | Alpha-Iduronidase Activity, Leukocytes | 24057-2 |
| 2011417 | Alpha-Iduronidase, Leukocytes, Interp | 48767-8 |
Aliases
- Hunter
- Hunter-Scheie
- Mucopolysaccharidosis Type I
- Scheie
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