Ordering Recommendation

Use to evaluate symptomatic patients for mucopolysaccharidoses (MPS). To monitor glycosaminoglycans (GAGs) in patients previously diagnosed with MPS, refer to Mucopolysaccharides, Quantitative, Urine (0081357).

Mnemonic
MPS SCREEN
Methodology

Electrophoresis/Spectrophotometry

Performed

Tue

Reported

4-14 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Morning void preferred.

Collect

Urine.

Specimen Preparation

Freeze specimen immediately. Transport 20 mL urine. (Min: 10 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Specimens containing preservatives.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Reference Interval
Test Number
Components
Reference Interval
  MPS Electrophoresis By report
0081357 Mucopolysaccharides, Quantitative, Urine 0-5 months: 14.6-47.8 mg/mmol creatinine
6-11 months: 3.7-35.5 mg/mmol creatinine
1-2 years: 5.4-30.8 mg/mmol creatinine
3-6 years: 5.2-16.7 mg/mmol creatinine
7-13 years: 2.4-10.2 mg/mmol creatinine
14 years or older: 0.0-7.1 mg/mmol creatinine

Interpretive Data

Mucopolysaccharides (Glycosaminoglycans) include:  Keratan Sulfate, Heparan Sulfate, Dermatan Sulfate, and Chondroitin Sulfates 4 and 6.  The excretion of Heparan Sulfate is variable.  A normal mucopolysaccharides screen does not exclude Sanfilippo Syndrome (Mucopolysaccharidosis Type III).

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

82664; 83864

Components
Component Test Code* Component Chart Name LOINC
0081353 MPS Electrophoresis
0081355 Mucopolysaccharides mg/mmol CRT 46132-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Chondroitin Sulfate
  • Dermatan Sulfate
  • GAG(s)
  • Glycosaminoglycans
  • Heparan Sulfate
  • Urine mucopolysaccharides
  • urine mucopolysaccharides screen
Mucopolysaccharides Screen - Electrophoresis and Quantitation, Urine