Use to evaluate symptomatic patients for mucopolysaccharidoses (MPS). To monitor glycosaminoglycans (GAGs) in patients previously diagnosed with MPS, refer to Mucopolysaccharides, Quantitative, Urine (0081357).
New York DOH Approval Status
Morning void preferred.
Freeze specimen immediately. Transport 20 mL urine. (Min: 10 mL)
Specimens containing preservatives.
Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month (avoid repeated freeze/thaw cycles)
|MPS Electrophoresis||By report|
|0081357||Mucopolysaccharides, Quantitative, Urine||0-5 months: 14.6-47.8 mg/mmol creatinine
6-11 months: 3.7-35.5 mg/mmol creatinine
1-2 years: 5.4-30.8 mg/mmol creatinine
3-6 years: 5.2-16.7 mg/mmol creatinine
7-13 years: 2.4-10.2 mg/mmol creatinine
14 years or older: 0.0-7.1 mg/mmol creatinine
Mucopolysaccharides (Glycosaminoglycans) include: Keratan Sulfate, Heparan Sulfate, Dermatan Sulfate, and Chondroitin Sulfates 4 and 6. The excretion of Heparan Sulfate is variable. A normal mucopolysaccharides screen does not exclude Sanfilippo Syndrome (Mucopolysaccharidosis Type III).
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0081355||Mucopolysaccharides mg/mmol CRT||46132-7|
- Chondroitin Sulfate
- Dermatan Sulfate
- Heparan Sulfate
- Urine mucopolysaccharides
- urine mucopolysaccharides screen