Ordering Recommendation

Acceptable initial test when antiphospholipid syndrome (APS) is strongly suspected. More specific than cardiolipin IgG and IgM antibodies in the diagnosis of APS.

Mnemonic
HS APL
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun

Reported

1-8 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, heat-inactivated, grossly hemolyzed, grossly icteric, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
Test Number
Components
Reference Interval
  High-Specificity Antiphospholipid Ab IgG
14 GPL or less Negative
15-26 GPL Indeterminate - Repeat testing in 12 weeks
27 GPL or greater Positive

  High-Specificity Antiphospholipid Ab IgM
14 MPL or less Negative
15-37 MPL Indeterminate - Repeat testing in 12 weeks
38 MPL or greater Positive

Interpretive Data

High-specificity antiphospholipid IgG and IgM antibodies are directed against a mixture of phosphatidylserine, phosphatidic acid, and beta-2 glycoprotein 1 antigens. These antibodies are more specific than cardiolipin IgG and IgM antibodies in the diagnosis of antiphospholipid syndrome (APS).

Compliance Category

FDA

Note

GPL = IgG phospholipid units; MPL = IgM phospholipid units

Hotline History
N/A
CPT Codes

83516 x2

Components
Component Test Code* Component Chart Name LOINC
2005458 High-Specificity Antiphospholipid Ab IgG 7801-4
2005459 High-Specificity Antiphospholipid Ab IgM 7802-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • APS-HS
High-Specificity Antiphospholipid Antibodies, IgG and IgM