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Phosphatidylserine Antibodies, IgG and IgM
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Ordering Recommendation
Preferred second-line test when seronegative antiphospholipid syndrome (APS) is strongly suspected. Order incrementally or concurrently with other noncriteria antiphospholipid antibody tests.
Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun, Tue, Wed, Fri, Sat
Reported
1-3 days
New York DOH Approval Status
Specimen Required
Serum separator tube
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Refrigerated
Heat-inactivated, contaminated, grossly icteric, grossly hemolyzed, or severely lipemic specimens
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
Reference Interval
Interpretive Data
IgG and/or IgM antibodies to phosphatidylserine (aPS) may be associated with a positive test for anti-cardiolipin autoantibodies (aCL) and risk for obstetric antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein antibodies.
Isolated presence of IgM or IgG antibodies to aPS may have questionable clinical significance for APS and/or SLE.
If results are positive, repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies.
Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.
FDA
Note
Hotline History
Hotline History
CPT Codes
86148 x2
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050906 | Phosphatidylserine Antibody IgG | 32032-5 |
| 0050907 | Phosphatidylserine Antibody IgM | 32033-3 |
Aliases
- Anti-Phosphatidylserine
- Anti-Phosphatidylserine (aPS)
- Antiphosphatidylserine
- aPS Antibodies IgG, IgM, IgA
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