Ordering Recommendation

Preferred second-line test when seronegative antiphospholipid syndrome is strongly suspected. Order incrementally or concurrently with other noncriteria antiphospholipid antibody tests.

Mnemonic
PHOSSER GM
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun, Tue, Wed, Fri, Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

Heat-inactivated, contaminated, grossly icteric, grossly hemolyzed, or severely lipemic specimens

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
Test Number
Components
Reference Interval
  Phosphatidylserine Antibody IgG Less than 11 U/mL
  Phosphatidylserine Antibody IgM Less than  25 U/mL

Interpretive Data

IgG and/or IgM antibodies to phosphatidylserine (aPS) may be associated with a positive test for anti-cardiolipin autoantibodies (aCL) and risk for obstetric antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein antibodies.

Isolated presence of IgM or IgG antibodies to aPS may have questionable clinical significance for APS and/or SLE.

If results are positive, repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies.

Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.

No compliance statements are in use for this test.

Note
Hotline History
N/A
CPT Codes

86148 x2

Components
Component Test Code* Component Chart Name LOINC
0050906 Phosphatidylserine Antibody IgG 32032-5
0050907 Phosphatidylserine Antibody IgM 32033-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-Phosphatidylserine
  • Anti-Phosphatidylserine (aPS)
  • Antiphosphatidylserine
  • aPS Antibodies IgG, IgM, IgA
Phosphatidylserine Antibodies, IgG and IgM