Ordering Recommendation

Preferred second-line test when seronegative antiphospholipid syndrome (APS) is strongly suspected. Order incrementally or concurrently with other noncriteria antiphospholipid antibody tests.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Serum separator tube

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature


Unacceptable Conditions

Heat-inactivated, contaminated, grossly icteric, grossly hemolyzed, or severely lipemic specimens


After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month


Semi-Quantitative Enzyme-Linked Immunosorbent Assay


Sun, Tue, Wed, Fri, Sat


1-4 days

Reference Interval

Test Number
Reference Interval
  Phosphatidylserine Antibody IgG Less than 16 GPS
  Phosphatidylserine Antibody IgM Less than  22 MPS

Interpretive Data

IgG and/or IgM antibodies to phosphatidylserine (aPS) may be associated with a positive test for anti-cardiolipin autoantibodies (aCL) and risk for obstetric antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein antibodies.

Isolated presence of IgM or IgG antibodies to aPS may have questionable clinical significance for APS and/or SLE.

If results are positive, repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies.

Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.

Compliance Category



Hotline History


CPT Codes

86148 x2


Component Test Code* Component Chart Name LOINC
0050906 Phosphatidylserine Antibody IgG 32032-5
0050907 Phosphatidylserine Antibody IgM 32033-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Anti-Phosphatidylserine
  • Anti-Phosphatidylserine (aPS)
  • Antiphosphatidylserine
  • aPS Antibodies IgG, IgM, IgA
Phosphatidylserine Antibodies, IgG and IgM