Ordering Recommendation

Aids in the diagnosis of histoplasmosis. Recommend testing in conjunction with Histoplasma Antibodies by Complement Fixation and Immunodiffusion (0050627) and Histoplasma Galactomannan Antigen Quantitative by EIA, Urine (2009418).

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to a sterile ARUP Standard Transport Tube (ARUP Supply #43115). (Min: 1 mL)
New York State Clients: 2 mL (Min: 1.2 mL)

Storage/Transport Temperature


Unacceptable Conditions

Specimen types other than those listed.


Ambient: Unacceptable; Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles) New York State Clients: Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: Indefinitely


Quantitative Enzyme Immunoassay (EIA)


Mon, Wed, Fri


1-4 days

Reference Interval

Not Detected

Interpretive Data

The quantitative range of this assay is 0.19-60.0 ng/mL. Antigen concentrations less than 0.19ng/mL ;greater than 60.0 ng/mL fall outside the linear range of the assay and cannot be accurately quantified.

This EIA test should be used in conjunction with other diagnostic procedures, including microbiological culture, histological examination of biopsy samples, serology and/or radiographic evidence, to aid in the diagnosis of histoplasmosis.

Cross-reactivity with Blastomyces dermatiditis, Coccidioides immitis, and possibly Talaromyces marneffei have been observed with this EIA. Other clinically and geographically relevant endemic mycoses should be considered in the case of a positive test result.

Compliance Category

Laboratory Developed Test (LDT)


For urine, refer to test Histoplasma Galactomannan Antigen Quantitative by EIA, Urine (ARUP test code 2009418).

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0060749 Histoplasma Antigen, Serum 51753-2
0092523 Histoplasma Antigen, Serum Interp 44525-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Histoplasma antigen immunoassay
  • serum histoplasma
Histoplasma Antigen Quantitative by EIA, Serum