• Assess patient with possible paraneoplastic pemphigus (PNP), a RARE paraneoplastic disease associated with lymphoproliferative disorders/malignancies and severe pemphigus clinical features with characteristic IgG antibodies to rodent substrates.
• If other, more common, types of pemphigus are of diagnostic consideration, order Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG (0090650) first or concurrently with this test.
• If IgA paraneoplastic antibody testing is required, request through ARUP Client Services 800-242-2787 option 2.
Indirect Fluorescent Antibody
Plain red or serum separator tube (SST).
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Hemolyzed or lipemic specimens.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
No compliance statements are in use for this test.
The methodology is indirect immunofluorescence (IFA) of patient serum on substrates from rodents including mouse heart, liver, bladder and rat bladder to detect characteristic staining: intercalated discs in heart; portal tracts in liver; and simple columnar epithelium cell surface and basement membrane zone in bladders. For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
88346; 88350 x4
|Component Test Code*||Component Chart Name||LOINC|
|0092107||Paraneoplastic Pemphigus Ab Screen||42936-5|