Ordering Recommendation

Use as antibody panel for initial assessment and disease monitoring in paraneoplastic pemphigus, a rare paraneoplastic disease associated with lymphoproliferative disorders/malignancies and severe pemphigus clinical features with characteristic IgG antibodies detected on rodent substrates including rat bladder. Testing should be clinically supported and/or correlated with concurrent Cutaneous Direct Immunofluorescence, Biopsy (0092572).

Consider ordering concurrently with Immunobullous Disease Panel, Epithelial (3001409) for broad epithelial antibody testing; alternatively, order with Desmoglein 1 and Desmoglein 3 Antibodies in Pemphigus, IgG (0090649) and Bullous Pemphigoid Antigens (180 kDa and 230 kDa), IgG (0092566); any of these epithelial antibodies may be increased in paraneoplastic pemphigus.

If other, more common, types of pemphigus are diagnostic considerations, order Pemphigus Antibody Panel, IgG (0090650) concurrently with this test.

If IgA paraneoplastic antibody testing is indicated, contact ARUP Client Services to request testing.




Semi-Quantitative Indirect Fluorescent Antibody (IFA)




3-7 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Hemolyzed or lipemic specimens.


Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Reference Interval

By report

Interpretive Data

Compliance Category

Not Applicable


The methodology is indirect immunofluorescence (IFA) of patient serum on substrates from rodents including mouse heart, liver, bladder and rat bladder to detect characteristic staining: intercalated discs in heart; portal tracts in liver; and simple columnar epithelium cell surface and basement membrane zone in bladders. For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.

Hotline History


CPT Codes

88346; 88350 x4


Component Test Code* Component Chart Name LOINC
0092107 Paraneoplastic Pemphigus Ab Screen 42936-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


Paraneoplastic Pemphigus Antibody Screen