Paraneoplastic Pemphigus (Paraneoplastic Autoimmune Multiorgan Syndrome) Screening Antibodies by IIF

Not a preferred initial test for paraneoplastic pemphigus; refer to Paraneoplastic Pemphigus (Paraneoplastic Autoimmune Multiorgan Syndrome) Expanded Antibody Panel by IIF With ELISA (3016534) for preferred initial combination testing with ELISA for IgG envoplakin antibodies and indirect immunofluorescence for rat bladder and other rodent substrate antibodies. This screening test includes only indirect immunofluorescence with rodent substrates; it may be used if IgG envoplakin antibody ELISA testing has been performed separately and for monitoring antibodies in patients with paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome who do not have increased IgG envoplakin antibodies. Results from this test should be correlated with Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572), histopathological examination of formalin-fixed tissue, testing for IgG envoplakin antibodies if performed separately [refer to Envoplakin Antibody, IgG by ELISA (3016533)], and assessment of other epithelial antibodies. 

For more information about components, methodology, and specimen type, refer to the ARUP Immunobullous Disease Testing Comparison tool.