Estradiol (Adult Premenopausal Females or Individuals on Estrogen Hormone Therapy)

0070045
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Standard

Ordering Recommendation

Use this immunoassay to measure estradiol in adult premenopausal cisgender females and individuals on estrogen hormone therapies. Not recommended when low estradiol concentrations, such as those found in children, cisgender males, and postmenopausal females, are expected, or for monitoring antiestrogen (eg, aromatase inhibitor) therapy. The preferred estradiol test in these cases is Estradiol (Adult Males, Children, Postmenopausal Females, or Individuals on Estrogen-Suppressing Hormone Therapy) (0093247). Not recommended in the evaluation of estradiol status for individuals with protein-binding abnormalities or individuals on hormonal contraception. The preferred estradiol test for these individuals is Estradiol, Free, by Dialysis and Mass Spectrometry (2006160).

To compare this test to other estrogen tests, refer to the ARUP Estrogen Tests Comparison table.

Mnemonic

ESTRA

Methodology

Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST). Also acceptable: Green (Sodium or Lithium Heparin)

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.4 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Grossly hemolyzed or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 8 hours; Refrigerated: 1 week; Frozen: 6 months

Reference Interval

Effective May 11, 2021

Female
Follicular phase 27-122 pg/mL
Mid Cycle phase 95-433 pg/mL
Luteal Phase 49-291 pg/mL
Post-Menopausal Less than 41 pg/mL

Interpretive Data

This immunoassay is not recommended when low estradiol concentrations, such as those found in children, cisgender males, and postmenopausal females, are expected, or for monitoring antiestrogen (e.g., aromatase inhibitor) therapy. The preferred estradiol test in these cases is Estradiol (Adult Males, Children, Postmenopausal Females, or Individuals on Estrogen-Suppressing Hormone Therapy) (ARUP test code 0093247).

No reference intervals have been established for prepubertal females or for cisgender males. For a complete set of all established reference intervals, refer to ltd.aruplab.com/Tests/Pub/0070045

Compliance Category

FDA

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
05/11/2021
X
X
X
N/A

CPT Codes

82670

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Components

Component Test Code* Component Chart Name LOINC
0070045 Estradiol by Immunoassay 2243-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Estradiol, 17b
Estradiol (Adult Premenopausal Females or Individuals on Estrogen Hormone Therapy)