Estradiol (Adult Males, Children, Postmenopausal Females, or Individuals on Estrogen-Suppressing Hormone Therapy)
Ordering Recommendation
Use this mass spectrometry test to measure a wide range of estradiol concentrations. Most useful when low estradiol concentrations are expected, regardless of the patient’s sex assigned at birth. Use to monitor estradiol in individuals on estrogen-suppressing hormone therapies (eg, aromatase inhibitors or testosterone).
Mnemonic
Methodology
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-4 days
New York DOH Approval Status
Specimen Required
Serum separator tube, lavender (EDTA), pink (K2EDTA) or green (sodium or lithium heparin).
Separate serum or plasma from cells within 2 hours after collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min 0.3 mL) Indicate age and sex of patient on test request form AND specimen tube.
Refrigerated.
After separation from cells: Ambient: 48 hours; Refrigerated: 1 week; Frozen: 1 month
Reference Interval
Reference Intervals for Estradiol-Children |
||
---|---|---|
Tanner Stages I II III IV and V |
Males less than 8.0 pg/mL less than 10.0 pg/mL 1.0-35.0 pg/mL 3.0-35.0 pg/mL |
Females less than 56.0 pg/mL 2.0-133.0 pg/mL 12.0-277.0 pg/mL 2.0-259.0 pg/mL |
Age Group 7-9 10-12 13-15 16-17 |
Males less than 7.0 pg/mL less than 11.0 pg/mL 1.0-36.0 pg/mL 3.0-34.0 pg/mL |
Females less than 36.0 pg/mL 1.0-87.0 pg/mL 9.0-249.0 pg/mL 2.0-266.0 pg/mL |
Reference Intervals for Estradiol-Adults |
|
---|---|
Females 18 Years and Older |
Males 18 years and Older |
Pre-menopausal: Early Follicular: 30.0-100.0 pg/mL Late Follicular: 100.0-400.0 pg/mL Luteal: 50.0-150.0 pg/mL |
10.0-42.0 pg/mL |
Postmenopausal: 2.0-21.0 pg/mL |
Interpretive Data
For a complete set of all established reference intervals, refer to ltd.aruplab.com/Tests/Pub/0093247.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
82670
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0093247 | Estradiol by Mass Spec | 35384-7 |
Aliases
- Estradiol (E2)
- Ultrasensitive Estradiol