Ordering Recommendation

Suitable for measurement of estradiol in men, children, or postmenopausal women.  Preferred test for adult premenopausal women is Estradiol, Adult Premenopausal Female, Serum or Plasma (0070045).

Mnemonic

ESDIOL TMS

Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube, lavender (EDTA), pink (K2EDTA) or green (sodium or lithium heparin).

Specimen Preparation

Separate serum or plasma from cells within 2 hours after collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min 0.3 mL) Indicate age and sex of patient on test request form AND specimen tube.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 1 week; Frozen: 1 month

Reference Interval

Reference Intervals for Estradiol-Children
Tanner Stages
I
II
III
IV and V
Males
less than 8.0 pg/mL
less than 10.0 pg/mL
1.0-35.0 pg/mL
3.0-35.0 pg/mL
Females
less than 56.0 pg/mL
2.0-133.0 pg/mL
12.0-277.0 pg/mL
2.0-259.0 pg/mL
Age Group
7-9
10-12
13-15
16-17
Males
less than 7.0 pg/mL
less than 11.0 pg/mL
1.0-36.0 pg/mL
3.0-34.0 pg/mL
Females
less than 36.0 pg/mL
1.0-87.0 pg/mL
9.0-249.0 pg/mL
2.0-266.0 pg/mL

Reference Intervals for Estradiol-Adults
Females 18 Years and Older
Males 18 years and Older
Pre-menopausal:
Early Follicular: 30.0-100.0 pg/mL
Late Follicular: 100.0-400.0 pg/mL
Luteal: 50.0-150.0 pg/mL
10.0-42.0 pg/mL
Postmenopausal: 2.0-21.0 pg/mL

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

82670

Components

Component Test Code* Component Chart Name LOINC
0093247 Estradiol by TMS 35384-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Estradiol (E2)
  • Ultrasensitive Estradiol
Estradiol, Males, Children or Postmenopausal Females by Tandem Mass Spectrometry