Ordering Recommendation

Suitable for measurement of estradiol in men, children, or postmenopausal women.  Preferred test for adult premenopausal women is Estradiol, Adult Premenopausal Female, Serum or Plasma (0070045).

Mnemonic
ESDIOL TMS
Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube, lavender (EDTA), pink (K2EDTA) or green (sodium or lithium heparin).

Specimen Preparation

Separate serum or plasma from cells within 2 hours after collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min 0.3 mL) Indicate age and sex of patient on test request form AND specimen tube.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 1 week; Frozen: 1 month

Reference Interval
Reference Intervals for Estradiol-Children
Tanner Stages
I
II
III
IV and V
Males
less than 8.0 pg/mL
less than 10.0 pg/mL
1.0-35.0 pg/mL
3.0-35.0 pg/mL
Females
less than 56.0 pg/mL
2.0-133.0 pg/mL
12.0-277.0 pg/mL
2.0-259.0 pg/mL
Age Group
7-9
10-12
13-15
16-17
Males
less than 7.0 pg/mL
less than 11.0 pg/mL
1.0-36.0 pg/mL
3.0-34.0 pg/mL
Females
less than 36.0 pg/mL
1.0-87.0 pg/mL
9.0-249.0 pg/mL
2.0-266.0 pg/mL

Reference Intervals for Estradiol-Adults
Females 18 Years and Older
Males 18 years and Older
Pre-menopausal:
Early Follicular: 30.0-100.0 pg/mL
Late Follicular: 100.0-400.0 pg/mL
Luteal: 50.0-150.0 pg/mL
10.0-42.0 pg/mL
Postmenopausal: 2.0-21.0 pg/mL

Interpretive Data



Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
CPT Codes

82670

Components
Component Test Code* Component Chart Name LOINC
0093247 Estradiol by TMS 35384-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Estradiol (E2)
  • Ultrasensitive Estradiol
Estradiol, Males, Children or Postmenopausal Females by Tandem Mass Spectrometry