Ordering Recommendation
Not a recommended panel for the diagnosis of antiphospholipid syndrome (APS). The Cardiolipin Antibodies, IgG and IgM (0099344) is preferred.
Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Refrigerated.
Plasma or other body fluids. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval
Test Number |
Components |
Reference Interval |
||||||||
---|---|---|---|---|---|---|---|---|---|---|
0050901 | Cardiolipin Antibody, IgG | Effective November 15, 2021
|
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0050902 | Cardiolipin Antibody, IgM | Effective November 15, 2021
|
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0098358 | Cardiolipin Antibody, IgA | Effective August 18, 2014
|
Interpretive Data
The persistent presence of IgG and/or IgM cardiolipin (CL) antibodies in moderate or high levels (greater than 40 GPL and/or greater than 40 MPL units) is a laboratory criterion for the diagnosis of antiphospholipid syndrome (APS). Persistence is defined as moderate or high levels of IgG and/or IgM CL antibodies detected in two or more specimens drawn at least 12 weeks apart (J Throm Haemost. 2006;4:295-306). Lower positive levels of IgG and/or IgM CL antibodies (above cutoff but less than 40 GPL and/or less than 40 MPL units) may occur in patients with the clinical symptoms of APS; therefore, the actual significance of these levels is undefined. Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.
FDA
Note
Hotline History
Hotline History
CPT Codes
86147 x3
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050901 | Cardiolipin Antibody IgG | 3181-5 |
0050902 | Cardiolipin Antibody IgM | 3182-3 |
0098358 | Cardiolipin Antibody IgA | 5076-5 |
Aliases
- ACA
- aCL Antibodies
- aCL Antibody
- Anticardiolipin Antibodies
- Cardiolip
- Cardiolipin Antibodies, IgA, IgG, IgM