MPO/PR3 (ANCA) Antibodies

0050707
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Example Reports
Negative
Positive

Ordering Recommendation

Use to monitor previously established MPO/PR3 antibodies or confirm an IFA ANCA positive test result. Test does not include ANCA testing by IFA. For ANCA testing, refer to the available panel tests. For the workup of suspected vasculitis, refer to ANCA-Associated Vasculitis Profile (ANCA/MPO/PR3) (3003745). For patients with a history of vasculitis, refer to Myeloperoxidase (MPO) Antibody and Serine Proteinase 3 (PR3) Antibody with Reflex to Anti-Neutrophil Cytoplasmic Antibody, IgG by IFA (3003746).

Mnemonic

MPO/PR3

Methodology

Semi-Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma, urine, or other body fluids.  Contaminated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
 Components
 Reference Interval (AU\mL)
  Myeloperoxidase (MPO) Ab, IgG 19 AU/mL or less
  Serine Proteinase 3 (PR3) Ab, IgG 19 AU/mL or less

Interpretive Data

Approximately 90% of patients with a P-ANCA pattern by IFA have antibodies specific for MPO. 
Approximately 85% of patients with a C-ANCA pattern by IFA have antibodies specific for PR3.


Component Interpretation
Myeloperoxidase (MPO) Antibody Negative           19 AU/mL or less
Equivocal          20-25 AU/mL
Positive           26 AU/mL or greater
Serine Proteinase 3 (PR3) Antibody Negative          19 AU/mL or less
Equivocal         20-25 AU/mL
Positive          26 AU/mL or greater

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

83516 x2

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Components

Component Test Code* Component Chart Name LOINC
0050526 Myeloperoxidase (MPO) Ab, IgG 6969-0
0050527 Serine Proteinase 3 (PR3) Ab, IgG 6968-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 3-ANCA
  • ANCA Antibodies
  • Anticytoplasmic Autoantibodies
  • c-ANCA
  • MPO
  • MPO-ANCA
  • Myeloperoxidase Antibodies
  • p-ANCA
  • PR3
  • PR3-ANCA
  • Proteinase 3 Antibodies
  • Serine Proteinase 3
MPO/PR3 (ANCA) Antibodies