Ordering Recommendation
When used in conjunction with other autoantibody tests (ANCA, PR3), may assist in evaluating suspected immune-mediated vasculitis, especially microscopic polyangiitis (MPA). May be useful when monitoring MPA disease and/or treatment response.
Panel tests are available. For the workup of suspected vasculitis, refer to ANCA-Associated Vasculitis Profile (ANCA/MPO/PR3) Reflex to ANCA Titer (2006480). For patients with a history of vasculitis, refer to the ANCA Reflex to Titer and MPO/PR3 Antibodies (2002068).
Mnemonic
Methodology
Semi-Quantitative Multiplex Bead Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)
Refrigerated.
Plasma, urine, or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
Negative | 19 AU/mL or less |
Equivocal | 20-25 AU/mL |
Positive | 26 AU/mL or greater |
Interpretive Data
Approximately 90% of patients with a P-ANCA pattern by IFA have antibodies specific for MPO.
FDA
Note
Hotline History
Hotline History
CPT Codes
83516
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050526 | Myeloperox Antibodies, IgG | 6969-0 |
Aliases
- MPO
- MPO Ab
- PR3