Ordering Recommendation

Confirm current or recent infection with group A Streptococcus in patients suspected of having a nonsuppurative complication such as acute glomerulonephritis (AGN) or acute rheumatic fever (ARF). DNase-B Antibody (0050220) and Streptolysin O Antibody (ASO) (0050095) are generally ordered concurrently. Preferred test for rheumatic chorea since it remains elevated longer.

Mnemonic
DNSB
Methodology

Quantitative Nephelometry

Performed

Sun, Wed, Fri

Reported

1-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or severely hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

0-6 years: Less than 250 U/mL
7-17 years: Less than 310 U/mL
18 years and older: Less than 260 U/mL

Interpretive Data



Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

86215

Components
Component Test Code* Component Chart Name LOINC
0050220 DNAse B Antibody 5133-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • DNase-B, Anti
  • ADB (Antideoxyribonuclease B)
  • Anti-Dnase B
  • Anti-DNase-B Antibody
  • Anti-Hyaluronidase
  • Antideoxyribonuclease B (ADB)
  • Antideoxyribonulease
  • DNA Streptococcal Antibody
  • Hyaluronidase
  • Serum Dnase-B Antibody
  • Streptococcal Antibodies, Serum
DNase-B Antibody