0050220
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DNase-B Antibody

DNSB
Example Reports
Abnormal
Normal

Ordering Recommendation

Confirm current or recent infection with group A Streptococcus in patients suspected of having a nonsuppurative complication such as acute glomerulonephritis (AGN) or acute rheumatic fever (ARF). DNase-B Antibody (0050220) and Streptolysin O Antibody (ASO) (0050095) are generally ordered concurrently. Preferred test for rheumatic chorea since it remains elevated longer.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.4 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or severely hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: 2 hours; Refrigerated: 8 days; Frozen: 3 months

Methodology

Quantitative Nephelometry

Performed

Sun-Sat

Reported

1-4 days

Reference Interval

0-6 years: Less than 250 U/mL
7-17 years: Less than 310 U/mL
18 years and older: Less than 260 U/mL

Interpretive Data

Elevated titers of antideoxyribonuclease B antibody (anti-DNase B) or antistreptolysin O antibody (ASO) indicate a recent group A Streptococcus infection. Anti-DNase B antibodies typically remain elevated longer than ASO and may remain elevated for several months after infection. Patients suspected of having complications related to a recent Streptococcus infection such as acute glomerulonephritis or acute rheumatic fever may have elevated anti-DNase B but normal ASO antibody titers. A negative or very low anti-DNase B and ASO antibody titers, especially from a specimen tested 2 weeks after a suspected infection, indicates unlikely incidence of a recent Streptococcus infection.

Compliance Category

FDA

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/21/2023
X
X
X
N/A

CPT Codes

86215

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Components

Component Test Code* Component Chart Name LOINC
0050220 DNAse B Antibody 5133-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • DNA Streptococcal Antibody
  • Anti-Dnase B
  • Anti-DNase-B Antibody
  • Antideoxyribonulease
  • Anti-Hyaluronidase
  • Antideoxyribonuclease B (ADB)
  • Hyaluronidase
  • Serum Dnase-B Antibody
  • Streptococcal Antibodies, Serum
  • DNase-B, Anti
  • ADB (Antideoxyribonuclease B)
DNase-B Antibody