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Streptolysin O Antibody (ASO)
Ordering Recommendation
Confirm a prior infection with group A Streptococcus in patients suspected of having a nonsuppurative complication such as acute glomerulonephritis (AGN) or acute rheumatic fever (ARF). DNase-B Antibody (0050220) and Streptolysin O Antibody (ASO) (0050095) antibody tests are generally ordered concurrently.
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.4 mL)
Refrigerated.
Hemolyzed specimens.
After separation from cells: Ambient: 8 hours; Refrigerated: 8 days; Frozen: 3 months
Methodology
Quantitative Nephelometry
Performed
Sun-Sat
Reported
Within 24 hours
Reference Interval
0-1 year: Less than 200 IU/mL
2-12 years: Less than 240 IU/mL
13 years and older: Less than 330 IU/mL
Interpretive Data
Elevated titers of antideoxyribonuclease B antibody (anti-DNase B) or antistreptolysin O antibody (ASO) indicate a recent group A Streptococcus infection. Anti-DNase B antibodies typically remain elevated longer than ASO and may remain elevated for several months after infection. Patients suspected of having complications related to a recent Streptococcus infection such as acute glomerulonephritis or acute rheumatic fever may have elevated anti-DNase B but normal ASO antibody titers. A negative or very low anti-DNase B and ASO antibody titers, especially from a specimen tested 2 weeks after a suspected infection, indicates unlikely incidence of a recent Streptococcus infection.
FDA
Note
Hotline History
Hotline History
CPT Codes
86060
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050095 | Streptolysin O Antibody | 5370-2 |
Aliases
- Anti-Streptolysin O Antibody
- ASO antibody test
- Streptococcal antibodies
