Ordering Recommendation

Acceptable initial test to detect activated protein C resistance due to a factor V Leiden variant. Preferred test is APC Resistance Profile with Reflex to Factor V Leiden (0030192).  However, Factor V Leiden (F5) R506Q Mutation (0097720) is the preferred initial test for individuals with supratherapeutic concentrations of heparin, direct thrombin inhibitors, Factor Xa inhibitors, extreme factor V deficiency, or lupus anticoagulants with markedly prolonged baseline clotting times.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 1.5 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. EDTA plasma, clotted or hemolyzed specimens.


Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months; Frozen at -70°C: 6 months


Electromagnetic Mechanical Clot Detection




1-4 days

Reference Interval

2.0 or greater

Interpretive Data

Ratios less than 2.00 suggest APC resistance. This method uses factor V deficient plasma; therefore, APC resistance due to a nonfactor V mutation will not be detected. Extreme factor V deficiency or presence of direct oral anticoagulants (DOACs) may cause an unreliable ratio.

Compliance Category



Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0030127 APC Resistance Panel 13590-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Activated Protein C Resistance
  • APCR
  • Factor V Leiden Functional Assay
  • Protein C Resistance
APC Resistance Profile