Acceptable initial test to detect activated protein C resistance due to a factor V Leiden variant. Preferred test is APC Resistance Profile with Reflex to Factor V Leiden (0030192). However, Factor V Leiden (F5) R506Q Mutation (0097720) is the preferred initial test for individuals with supratherapeutic concentrations of heparin, direct thrombin inhibitors, Factor Xa inhibitors, extreme factor V deficiency, or lupus anticoagulants with markedly prolonged baseline clotting times.
Electromagnetic Mechanical Clot Detection
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
Transfer 1.5 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Serum. EDTA plasma, clotted or hemolyzed specimens.
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months; Frozen at -70°C: 6 months
2.0 or greater
Ratios less than 2.00 suggest APC resistance. This method uses factor V deficient plasma; therefore, APC resistance due to a nonfactor V mutation will not be detected. Extreme factor V deficiency may cause abnormal ratio.
|Component Test Code*||Component Chart Name||LOINC|
|0030127||APC Resistance Panel||13590-5|
- Activated Protein C Resistance
- Factor V Leiden Functional Assay
- Protein C Resistance