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Paraneoplastic Pemphigus Antibody Screen
0092107
Ordering Recommendation
•Assess patient with possible paraneoplastic pemphigus (PNP), a RARE paraneoplastic disease associated with lymphoproliferative disorders/malignancies and severe pemphigus clinical features with characteristic IgG antibodies to rodent substrates.
•If other, more common, types of pemphigus are of diagnostic consideration, order the antibody panel test for pemphigus (0090650) first or concurrently with this test.
•If IgA paraneoplastic antibody testing is required, request through ARUP Client Services 800-242-2787 option 2.
Mnemonic
PARA PEMPH
Methodology
Indirect Fluorescent Antibody
Performed
Varies
Reported
3-7 days  
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
  
Collect
Plain red or serum separator tube (SST).  
Specimen Preparation
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Hemolyzed or lipemic specimens.  
Remarks
  
Stability
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely  
Reference Interval
By report  
Interpretive Data
 
Note
The methodology is indirect immunofluorescence (IFA) of patient serum on substrates from rodents including mouse heart, liver, bladder and rat bladder to detect characteristic staining: intercalated discs in heart; portal tracts in liver; and simple columnar epithelium cell surface and basement membrane zone in bladders. For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
CPT Code(s)
88347 x5
Components
Component Test Code*Component Chart NameLOINC
0092107Paraneoplastic Pemphigus Ab Screen42936-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
 

Performed at UUHC-Immunodermatology