Paraneoplastic pemphigus (PNP) is a rare type of pemphigus associated with lymphoproliferative disorders and malignancy. If other types of pemphigus have not been ruled out, order Pemphigus Antibody Panel (0090650
) first or concurrently with this test. Only IgG PNP antibodies reported; if IgA PNP antibody testing desired, make request through University Client Services 801-581-2430.
Indirect Fluorescent Antibody
This test is New York DOH approved.
- Patient Preparation
- Plain red or serum separator tube (SST).
- Specimen Preparation
- Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
- Storage/Transport Temperature
- Unacceptable Conditions
- Hemolyzed or lipemic specimens.
- Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
The methodology is indirect immunofluorescence (IFA) of patient serum on substrates from rodents including mouse heart, liver, bladder and rat bladder to detect characteristic staining: intercalated discs in heart; portal tracts in liver; and simple columnar epithelium cell surface and basement membrane zone in bladders. For specimens less than 0.5 mL, call the Immunodermatology Laboratory at (866) 266-5699.
|Component Test Code*||Component Chart Name|
|0092107||Paraneoplastic Pemphigus Ab Screen|
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Performed at UUHC-Immunodermatology