Cardiolipin Antibody, IgM
0050902
Ordering Recommendation
Acceptable initial test for strong suspicion of antiphospholipid syndrome (APS). Order with lupus anticoagulant (LA) (0030181) and anti-beta-2-glycoprotein 1 (anti-β2GP1) IgG and IgM (0050321) assays. Combined IgG and IgM cardiolipin (aCL) antibody test is preferred )0099344).
Submit With Order
Mnemonic
AC-IGM
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma or other body fluids. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
0-12 MPL: Negative
13-19 MPL: Indeterminate
20-80 MPL: Low to Medium Positive
81 MPL or above: High positive
Interpretive Data
Most patients with antiphospholipid antibody syndrome (APS) have medium or high levels of anticardiolipin IgG and/or IgM antibodies. All positive results should be retested on two or more occasions and at least 12 weeks apart to confirm persistence (J Thromb Haemost. 2006;4:295-306).
Note
MPL = IgM phospholipid units
CPT Code(s)
86147
Components
Component Test Code*Component Chart Name
0050902Cardiolipin Antibody IgM
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • ACA
  • aCL
  • aCL Antibody
  • aCL IgM
  • Anti-Cardiolipin
  • Anticardiolipin
  • Anticardiolipin Antibodies
  • Cardiolip