Acceptable initial test when antiphospholipid syndrome (APS) is strongly suspected. Order with Lupus Anticoagulant Reflexive Panel (0030181) and Cardiolipin Antibodies, IgG and IgM (0099344). May also be useful in estimating risk of thrombosis and/or pregnancy-related morbidity in patients with systemic lupus erythematosus (SLE).
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
New York DOH Approval Status
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Plasma or other body fluids. Contaminated, hemolyzed, grossly icteric, or severely lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
|B2Glycoprotein 1, IgG Antibody||Effective November 15, 2021
|B2Glycoprotein 1, IgM Antibody||Effective November 15, 2021
The persistent presence of IgG and/or IgM beta 2 glycoprotein I (B2GPI) antibodies is a laboratory criterion for the diagnosis of antiphospholipid syndrome (APS). Persistence is defined as moderate or high levels of IgG and/or IgM B2GPI antibodies detected in two or more specimens drawn at least 12 weeks apart (J Throm Haemost. 2006;4:295-306). B2GPI results greater than 20 SGU (IgG) and/or SMU (IgM) are considered positive based on the cutoff values established for this test. International reference materials and consensus units for anti-B2GPI antibodies have not been established (Clin Chim Acta. 2012;413(1-2):358-60; Arthritis Rheum. 2012;64(1):1-10.); results can be variable between different commercial immunoassays and cannot be compared. Strong clinical correlation is recommended for a diagnosis of APS. Low positive IgG and IgM B2GPI antibody levels should be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.
|Component Test Code*||Component Chart Name||LOINC|
|0050322||B2Glycoprotein 1, IgG Antibody||44448-9|
|0050323||B2Glycoprotein 1, IgM Antibody||44449-7|
- Anti-B2-Glycoprotein 1
- Anti-B2-Glycoprotein I
- Anti-B2-GP 1
- Anti-beta-2 glycoprotein 1
- Anti-Beta-2-Glycoprotein I
- Apolipoprotein H
- Apolipoprotein H, APOH
- B2-glycoprotein 1 antibodies
- B2GP Antibodies
- B2GPI IgG, IgM
- Beta 2 GP1 Ab IgG
- Beta 2 GP1 Ab IgM
- Beta 2GP1 Ab
- Beta-2 Glycoprotein 1