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Serine Protease 3 Antibody
0050527
Ordering Recommendation

• When used in conjunction with other autoantibody tests (ANCA, MPO), may assist in differentiating suspected Wegener granulomatosis (WG) from other vasculitides.
• May be useful when monitoring patients with PR-3 antibodies.
• Panel tests are available.
 ○ For the workup of suspected vasculitis, refer to ANCA-Associated Vasculitis Profile (ANCA/MPO/PR-3) Reflex to ANCA Titer (2006480).
 ○ For patients with a history of vasculitis, refer to the ANCA Reflex to Titer and MPO/PR-3 Antibodies (2002068).

Mnemonic
PR3
Methodology
Semi-Quantitative Multiplex Bead Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma, urine, or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Negative: 19 AU/mL or less
Equivocal: 20-25 AU/mL
Positive: 26 AU/mL or greater
Interpretive Data
Approximately 85% of patients with a C-ANCA pattern by IFA have antibodies specific for PR3.


Note
CPT Code(s)
83516
Components
Component Test Code*Component Chart NameLOINC
0050527Serine Protease3, IgG6968-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • PR3
  • PR3 Ab
  • PR3 IgG Antibodies