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Serine Protease 3 Antibody
0050527
Ordering Recommendation

•When used in conjunction with other autoantibody tests (ANCA, MPO), may assist in differentiating suspected Wegener granulomatosis (WG) from other vasculitides.
•May be useful when monitoring patients with PR-3 antibodies.
•Panel tests are available.
-For the workup of suspected vasculitis, refer to ANCA-Associated Vasculitis Profile (ANCA/MPO/PR-3) Reflex to ANCA Titer (2006480).
-For patients with a history of vasculitis, refer to the ANCA Reflex to Titer and MPO/PR-3 Antibodies (2002068).

Mnemonic
PR3
Methodology
Semi-Quantitative Multiplex Bead Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma, urine, or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Negative: 19 AU/mL or less
Equivocal: 20-25 AU/mL
Positive: 26 AU/mL or greater
Interpretive Data
Approximately 85% of patients with a C-ANCA pattern by IFA have antibodies specific for PR3.


Note
CPT Code(s)
83516
Components
Component Test Code*Component Chart NameLOINC
0050527Serine Protease3, IgG6968-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • PR3
  • PR3 Ab
  • PR3 IgG Antibodies