Ordering Recommendation

When used in conjunction with other autoantibody tests (ANCA, PR3), may aid in evaluating suspected immune-mediated vasculitis, especially microscopic polyangiitis (MPA). May be useful to monitor MPA disease and/or treatment response.

Panel tests are available. For the workup of suspected vasculitis, refer to ANCA-Associated Vasculitis Profile (ANCA/MPO/PR3) (3003745). For patients with a history of vasculitis, refer to Myeloperoxidase (MPO) Antibody and Serine Proteinase 3 (PR3) Antibody with Reflex to Anti-Neutrophil Cytoplasmic Antibody, IgG by IFA (3003746).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma, urine, or other body fluids.  Contaminated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Methodology

Semi-Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-2 days

Reference Interval

Test Number
Components
Reference Interval
  Myeloperoxidase (MPO) Ab, IgG 19 AU/mL or less

Interpretive Data

Approximately 90% of patients with a P-ANCA pattern by IFA have antibodies specific for MPO.


Component
Interpretation
Myeloperoxidase (MPO) Antibody Negative           19 AU/mL or less
Equivocal          20-25 AU/mL
Positive           26 AU/mL or greater

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

83516

Components

Component Test Code* Component Chart Name LOINC
0050526 Myeloperoxidase (MPO) Ab, IgG 6969-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • MPO
  • MPO Ab
  • PR3
Myeloperoxidase (MPO) Antibody