Histoplasma Antigen Quantitative by EIA, Serum
Ordering Recommendation

Aid in the diagnosis of histoplasmosis. Recommend testing in conjunction with Histoplasma Antibodies by CF & ID (0050627) and Histoplasma Galactomannan Antigen Quantitative by EIA, Urine (2009418).

Quantitative Enzyme Immunoassay
Mon, Wed, Fri
1-4 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Plain Red or Serum Separator Tube (SST). 
Specimen Preparation
Transfer 2 mL serum to a sterile ARUP Standard Transport Tube (ARUP Supply #43115). (Min: 1 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Specimen types other than those listed. 
Ambient: Unacceptable; Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles) 
Reference Interval
Not Detected
Interpretive Data
The quantitative range of this assay is 0.19-60.0 ng/mL. Antigen concentrations less than 0.19ng/mL or greater than 60.0 ng/mL fall outside the linear range of the assay and cannot be accurately quantified.

This EIA test should be used in conjunction with other diagnostic procedures, including microbiological culture, histological examination of biopsy samples, serology and/or radiographic evidence, to aid in the diagnosis of histoplasmosis.

Crossreactivity with Blastomyces dermatiditis, Coccidioides immitis, and possibly Talaromyces marneffei have been observed with this EIA. Other clinically and geographically relevant endemic mycoses should be considered in the case of a positive test result.

Test developed and characteristics determined by ARUP Laboratories. See Compliance Statement B:

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

For urine, refer to test Histoplasma Galactomannan Antigen Quantitative by EIA, Urine (ARUP test code 2009418).
Hotline History
View Hotline History
Component Test Code*Component Chart NameLOINC
0060749Histoplasma Antigen, Serum6428-7
0092523Histoplasma Antigen, Serum Interp44525-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Histoplasma antigen immunoassay
  • serum histoplasma