Cardiolipin Antibodies, IgG, IgM, and IgA
Ordering Recommendation

Not a recommended panel for the diagnosis of antiphospholipid syndrome (APS). The Cardiolipin Antibodies, IgG and IgM (0099344) is preferred.

Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Within 24 hours
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum separator tube. 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Plasma or other body fluids. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens. 
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year 
Reference Interval
Test Number
Reference Interval
0050901Cardiolipin Antibody, IgGEffective August 18, 2014
0-14 GPLNegative
15-19 GPLIndeterminate
20-80 GPLLow to Moderately Positive
81 GPL or aboveHigh Positive

0050902Cardiolipin Antibody, IgMEffective August 18, 2014
0-12 MPLNegative
13-19 MPLIndeterminate
20-80 MPLLow to Moderately Positive
81 MPL or aboveHigh Positive

0098358Cardiolipin Antibody, IgAEffective August 18, 2014
0-11 APLNegative
12-19 APLIndeterminate
20-80 APLLow to Moderately Positive
81 APL or aboveHigh Positive

Interpretive Data
The persistent presence of IgG and/or IgM cardiolipin (CL) antibodies in moderate or high levels (greater than 40 GPL and/or greater than 40 MPL units or greater than 99th percentile) is a laboratory criterion for the diagnosis of antiphospholipid syndrome (APS). Persistence is defined as moderate or high levels of IgG and/or IgM CL antibodies detected in two or more specimens drawn at least 12 weeks apart (J Throm Haemost. 2006;4:295-306). Lower positive levels of IgG and/or IgM CL antibodies (above cutoff but less than 40 GPL and/or less than 40 MPL units) may occur in patients with the clinical symptoms of APS; therefore, the actual significance of these levels is undefined. Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.

Hotline History
Component Test Code*Component Chart NameLOINC
0050901Cardiolipin Antibody IgG3181-5
0050902Cardiolipin Antibody IgM3182-3
0098358Cardiolipin Antibody IgA5076-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • ACA
  • aCL Antibodies
  • aCL Antibody
  • Anticardiolipin Antibodies
  • Cardiolip
  • Cardiolipin Antibodies, IgA, IgG, IgM