Ordering Recommendation

Use this test for fetal genotyping to assess risk for alloimmune thrombocytopenia. For parental or neonatal genotyping, refer to Platelet Antigen Genotyping Panel (3000193). This test does not include antibody identification; for antibody identification, refer to Platelet Antibody Identification Panel (3017737).

Maternal cell contamination (MCC) analysis is required and performed at no additional charge. Order Maternal Cell Contamination, Maternal Specimen (0050608) on a maternal blood specimen.

For guidance on ordering maternal cell contamination studies, please refer to Maternal Cell Contamination (MCC) Analysis Guide.  

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Fetal Specimen: Amniotic fluid OR cultured amniocytes OR cultured chorionic villus sampling (CVS).
Maternal Specimen: Refer to Maternal Cell Contamination, Maternal Specimen (0050608) for maternal specimen requirements.

Specimen Preparation

Transport: 10 mL amniotic fluid (min: 5 mL) OR
Two T-25 flasks of 80% confluent cultured amniocytes OR
Two T-25 flasks of 80% confluent cultured chorionic villus sampling (CVS). If submitting uncultured (direct) amniotic fluid or (direct) CVS and testing is desired on a cultured specimen, add Cell Culture for Genetic Testing (3020627). If transporting flasks, the client is responsible for maintaining backup cultures at the client institution. If ARUP receives cultured fetal cells below minimum confluence, Cell Culture for Genetic Testing (3020627) will be added by ARUP.

Storage/Transport Temperature

Preferred transport: Room temperature.
Preferred shipment: Within two days of collection or confluence.

Unacceptable Conditions

Frozen specimens.

Remarks

Counseling and informed consent are recommended for genetic testing. Consent forms are linked above.
New York Clients: Informed consent is required with submission.

Stability

Room temperature: 2 days; Refrigerated: 2 days; Frozen: Unacceptable

Methodology

Polymerase Chain Reaction (PCR) / Fluorescence Monitoring / Fragment Analysis

Performed

Varies

Reported

7-14 days
If culture is required, an additional 1 to 2 weeks is required for processing time.

Reference Interval

Interpretive Data

Refer to report.

Compliance Category

Modified FDA

Note

Hotline History

N/A

CPT Codes

81105; 81106; 81107; 81108; 81109; 81110; 81112; 81265 Fetal Cell Contamination (FCC)

Components

Component Test Code* Component Chart Name LOINC
0050548 Maternal Contamination Study Fetal Spec 59266-7
0050612 Maternal Contam Study, Maternal Spec 66746-9
3001173 Platelet Antigen 1 Genotyping
3001174 Platelet Antigen 2 Genotyping
3001175 Platelet Antigen 3 Genotyping
3001176 Platelet Antigen 4 Genotyping
3001177 Platelet Antigen 5 Genotyping
3001178 Platelet Antigen 6 Genotyping
3001179 Platelet Antigen 15 Genotyping
3016674 Platelet Antigen Geno Fetal, Interp
3016675 Platelet Antigen Geno, Fetal Specimen
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • HPA platelet antigen genotyping panel
Platelet Antigen Genotyping Panel, Fetal