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Chimerism, Recipient, Pretransplant
Ordering Recommendation
Use to assess recipient genotype and compare to donor genotype prior to allogeneic hematopoietic stem cell transplant. Pretransplant genotyping is required to enable posttransplant chimerism and engraftment monitoring. For posttransplant monitoring, refer to Chimerism, Posttransplant (3005454).
New York DOH Approval Status
Specimen Required
Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B). OR bone marrow in lavender (EDTA). OR buccal brushes from recipient.
Transport 2 mL whole blood (Min: 1 mL), OR 1 mL bone marrow (Min: 1 mL), OR 2 buccal brushes in a sterile, dry tube. (Min: 2 brushes)
Refrigerated. Also acceptable: Ambient.
Posttransplant results will be compared to pretransplant recipient and donor genotypes, therefore, donor and recipient specimens must be obtained and genotyped before the transplant event occurs. If transplant event occurred prior to specimen collection, dry buccal brushes (not bloody) are acceptable.
Room temperature: 1 week; Refrigerated: 1 month; Frozen: Unacceptable
Methodology
Polymerase Chain Reaction (PCR)/Fragment Analysis
Performed
Sun-Sat
Reported
Varies
Reference Interval
Interpretive Data
Refer to report.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
81265
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3005450 | Chimerism Recipient Pre, Specimen | |
| 3005451 | Chimerism Recipient Pre,InformativeLoci | |
| 3005452 | Chimerism Recipient Pre, Interpretation |
Aliases
- Bone marrow DNA typing
- Chimerism evaluation
- Pre transplant evaluation
- Transplant analysis
- Transplant evaluation
